精神分裂症倾向水平高的人群中皮质-纹状体功能连接的改变：一项纵向静息态研究。
Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study.
作者信息
Wang Ling-Ling, Sun Xiaoqi, Chiu Chui-De, Leung Patrick W L, Chan Raymond C K, So Suzanne H W
机构信息
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, The University of Chinese Academy of Sciences, Beijing, China.
Department of Psychology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
出版信息
Asian J Psychiatr. 2021 Apr;58:102621. doi: 10.1016/j.ajp.2021.102621. Epub 2021 Feb 28.
PURPOSE OF THE RESEARCH
Cortico-striatal functional connectivity has been implicated in the neuropathology of schizophrenia. However, the longitudinal relationship between the cortico-striatal connectivity and schizotypy remains unknown. We examined the resting-state fMRI connectivity in 27 individuals with a high level of schizotypy and 20 individuals with a low level of schizotypy at baseline and 18 months later. Correlations between changes in cortico-striatal connectivity and changes in schizotypy scores over time were examined.
PRINCIPAL RESULTS
We found both increased and decreased cortico-striatal connectivity in individuals with a high level of schizotypy at baseline. Over time, these individuals showed improvement in both the negative and positive schizotypal domains. Changes in striatal-insula connectivity were positively correlated with changes in positive schizotypy from baseline to follow-up.
MAJOR CONCLUSIONS
Our results suggested impaired cortico-striatal connectivity in individuals with a high level of schizotypy. The dysconnectivity mainly involves the dorsal striatum. The connectivity between the dorsal striatum and the insula may be a putative marker for temporal changes in positive schizotypy.
研究目的
皮质-纹状体功能连接已被认为与精神分裂症的神经病理学有关。然而，皮质-纹状体连接与精神分裂症样特质之间的纵向关系仍然未知。我们在基线时和18个月后对27名精神分裂症样特质水平高的个体和20名精神分裂症样特质水平低的个体进行了静息态功能磁共振成像连接性检查。研究了皮质-纹状体连接性变化与精神分裂症样特质评分随时间变化之间的相关性。
主要结果
我们发现，基线时精神分裂症样特质水平高的个体中，皮质-纹状体连接性既有增加也有减少。随着时间的推移，这些个体在阴性和阳性精神分裂症样特质领域均有改善。从基线到随访，纹状体-脑岛连接性的变化与阳性精神分裂症样特质的变化呈正相关。
主要结论
我们的结果表明，精神分裂症样特质水平高的个体存在皮质-纹状体连接受损。这种连接障碍主要涉及背侧纹状体。背侧纹状体与脑岛之间的连接可能是阳性精神分裂症样特质随时间变化的一个假定标志物。
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