Mark-Vendel E, Philip I, Philip T, Lenoir G, Berger R, Mitelman F
International Agency for Research on Cancer, Lyon, France.
Leuk Res. 1988;12(3):263-5. doi: 10.1016/0145-2126(88)90145-2.
Twenty-six bone marrow samples from 21 patients with Burkitt's lymphoma were examined cytogenetically after short-term culture. Clonal chromosomal changes were detected in one of 18 samples from morphologically normal marrows, and in three out of six samples with verified tumor invasion. Three patients had the translocation (8;14)(q24;q32) and one had t(2;8)(p12;q24). Two samples with suspect tumor involvement (less than 5% putative tumor cells) showed no clonal abnormalities. In two samples without morphologic bone marrow infiltration and with only normal metaphases in short-term cultures, clones with t(8;14)(q24;q32) were revealed after a longer time (3-12 weeks) spent in vitro.
对21例伯基特淋巴瘤患者的26份骨髓样本进行短期培养后进行细胞遗传学检查。在形态学正常的骨髓的18份样本中有1份检测到克隆性染色体改变，在6份经证实有肿瘤浸润的样本中有3份检测到克隆性染色体改变。3例患者有(8;14)(q24;q32)易位，1例有t(2;8)(p12;q24)。两份怀疑有肿瘤累及（假定肿瘤细胞少于5%）的样本未显示克隆性异常。在两份无形态学骨髓浸润且短期培养中只有正常中期分裂相的样本中，体外培养较长时间（3 - 12周）后发现有t(8;14)(q24;q32)的克隆。
