Tominaga T, Suzuki H, Ogata Y, Imafuku T, Saruta T
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Life Sci. 1988;42(19):1861-8. doi: 10.1016/0024-3205(88)90025-2.
Effects of the synthetic bile acids on blood pressure were examined in spontaneously hypertensive rats. Continuous intravenous administration of the bile acids at the rate of 1 mg/min for 20 min significantly lowered the blood pressure by 12 mmHg. In order to examine its blood pressure lowering mechanism, the isolated mesenteric arterial perfusion system was employed. Bile acids in the perfusate inhibited vascular reactivity to norepinephrine and KCl in a dose-dependent manner. This inhibitory action diminished as the concentration of potassium in the perfusate decreased. When the perfusate was free from potassium, its inhibitory action completely disappeared. These results in vivo and in vitro studies strongly suggest that bile acids act directly on the vascular beds and attenuate vascular response to norepinephrine.
在自发性高血压大鼠中研究了合成胆汁酸对血压的影响。以1mg/分钟的速率持续静脉注射胆汁酸20分钟，可使血压显著降低12mmHg。为了研究其降压机制，采用了离体肠系膜动脉灌注系统。灌注液中的胆汁酸以剂量依赖的方式抑制血管对去甲肾上腺素和氯化钾的反应性。随着灌注液中钾浓度的降低，这种抑制作用减弱。当灌注液中无钾时，其抑制作用完全消失。这些体内和体外研究结果有力地表明，胆汁酸直接作用于血管床并减弱血管对去甲肾上腺素的反应。
