Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland.
Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, J. Chełmońskiego 37, Wroclaw, 51-630, Poland.
Sci Rep. 2017 Sep 28;7(1):12373. doi: 10.1038/s41598-017-12019-w.
Hypertension is the most common risk factor for stroke, coronary heart disease and heart failure, which are the leading causes of death worldwide. Dietary patterns and supplements intakes are becoming important factors in the hypertension. The aim of this study was to estimate the effects of new generation egg yolk phospholipids rich in lecithin (SL) esterified with omega-3 and omega-6 fatty acids on blood pressure in hypertensive rats (SHR). Here we have reported that lecithin (SL) derived from egg yolk lowers blood pressure in pathology of hypertension. The SHR rats treated with SL had significantly lower blood pressure than control group (157/104 vs. 178/121 mmHg; P < 0.05) and down-regulated mesenteric artery over-response to norepinephrine and potassium chloride, giving similar arterial response as for normotensive Wistar Kyoto rats (WKY). Hypertensive rats treated by SL demonstrated significantly lower serum level of inflammatory factors. This work also indicates that SL treatment lowers heart rate and reduces the serum level of oxidative stress marker - nitrotyrosine - by 30-34% in both hypertensive and normotensive animals. Phospholipids with lecithin derived from PUFA fortified eggs may be a valuable dietary supplement in prophylaxis of hypertension and in patients with hypertension, however, this requires further studies on humans.
高血压是中风、冠心病和心力衰竭的最常见风险因素，这些疾病是全球死亡的主要原因。饮食模式和补充剂的摄入正成为高血压的重要因素。本研究旨在评估富含 omega-3 和 omega-6 脂肪酸的新一代蛋黄磷脂（SL）对高血压大鼠（SHR）血压的影响。在这里，我们报道了蛋黄来源的磷脂（SL）可降低高血压患者的血压。与对照组（157/104 对 178/121mmHg；P<0.05）相比，用 SL 治疗的 SHR 大鼠的血压明显降低，并且下调肠系膜动脉对去甲肾上腺素和氯化钾的过度反应，使其与正常血压的 Wistar 京都大鼠（WKY）的动脉反应相似。用 SL 治疗的高血压大鼠的血清炎症因子水平显著降低。这项工作还表明，SL 治疗可降低心率，并使高血压和正常血压动物的血清氧化应激标志物-硝基酪氨酸水平降低 30-34%。用富含 PUFA 的鸡蛋强化的磷脂可能是高血压预防和高血压患者的有价值的膳食补充剂，但这需要进一步的人体研究。
