Redgrave T G, Maranhao R C, Tercyak A M, Lincoln E C, Brunengraber H
Biophysics Institute, Housman Medical Research Center, Boston University School of Medicine, MA 02118.
Lipids. 1988 Feb;23(2):101-5. doi: 10.1007/BF02535288.
In comparison with their precursor lipoproteins, the remanants of the triacylglycerol-rich lipoproteins are reduced in contents of triacylglycerols and apolipoproteins AI and AIV, whereas the contents of cholesterol (free and esterified) and apolipoprotien E are increased. In this study, lipid emulsion models of remnant lipoproteins were used to explore which of these factors are necessary for physiological rates of remnant uptake by the perfused rat liver. Uptake rates of lipid emulsion models of remnant lipoproteins in the presence of apolipoprotein E were similar to in vivo uptake rates.
与它们的前体脂蛋白相比，富含三酰甘油的脂蛋白残粒中的三酰甘油、载脂蛋白AI和AIV含量减少，而胆固醇（游离和酯化的）和载脂蛋白E的含量增加。在本研究中，使用残粒脂蛋白的脂质乳剂模型来探究这些因素中哪些是灌注大鼠肝脏以生理速率摄取残粒所必需的。载脂蛋白E存在时残粒脂蛋白脂质乳剂模型的摄取率与体内摄取率相似。
