妊娠期高血压内皮功能障碍的新观点及潜在治疗靶点
New views on endothelial dysfunction in gestational hypertension and potential therapy targets.
机构信息
First Hospital of Soochow University & Maternal and Child Health Care Hospital of Wuxi, Jiangsu, China; Department of Obstetrics, Affiliated Hospital of Jining Medical University, Shandong, China.
First Hospital of Soochow University & Maternal and Child Health Care Hospital of Wuxi, Jiangsu, China.
出版信息
Drug Discov Today. 2021 Jun;26(6):1420-1436. doi: 10.1016/j.drudis.2021.03.001. Epub 2021 Mar 4.
The placenta has vital roles in metabolite exchange, fetal growth, and pre-eclampsia (PE). In this review, we discuss the pathogenesis of hypertension in pregnancy, focusing on four major theories to explain PE, discussing endothelial roles in those theories. We focus in particular on the roles of nitric oxide (NO) and prostacyclin (PGI) in placental endothelium, and propose new hypotheses for the influence and mechanisms of endothelial NO and PGI signaling pathways in PE.
胎盘在代谢物交换、胎儿生长和子痫前期 (PE) 中起着至关重要的作用。在这篇综述中，我们讨论了妊娠高血压的发病机制，重点讨论了四种解释 PE 的主要理论，并讨论了内皮细胞在这些理论中的作用。我们特别关注了一氧化氮 (NO) 和前列环素 (PGI) 在胎盘内皮细胞中的作用，并提出了内皮细胞 NO 和 PGI 信号通路在 PE 中的影响和机制的新假设。
Zotero 插件