Department of Psychological Sciences, Kent State University, Kent, OH, USA.
Department of Psychology, University of Akron, Akron, OH, USA.
Cerebellum. 2021 Dec;20(6):872-886. doi: 10.1007/s12311-021-01251-w. Epub 2021 Mar 6.
Chiari malformation type I (CMI) provides an opportunity for examining possible moderators of allostatic load. CMI patients who had (n = 43) and had not (n = 19) undergone decompression surgery completed questionnaires regarding pain, disability, and loneliness, and provided serum samples for IL-6, CRP, estrogen, and free estradiol assays, and saliva samples to assess diurnal cortisol curves. ANOVAs examining surgical status (decompressed versus non-decompressed), loneliness (high vs. low), and disability (high vs. low) as independent variables and biomarker variables as dependent factors found that loneliness was associated with higher levels of cortisol, F(1, 37) = 4.91, p = .04, η = .11, and lower levels of estrogen, F(1, 36) = 7.29, p = .01, η = .17, but only in decompressed patients. Results highlight the possible impact of loneliness on biological stress responses and the need to intervene to reduce loneliness in patients with symptomatic CMI.
颅底凹陷症 I 型 (CMI) 为研究适应负荷的可能调节因素提供了机会。完成了关于疼痛、残疾和孤独感的问卷，并提供了血清样本以进行白细胞介素 6 (IL-6)、C 反应蛋白 (CRP)、雌激素和游离雌二醇检测，以及唾液样本以评估日间皮质醇曲线的 CMI 患者（n = 43）和未接受减压手术的 CMI 患者（n = 19）。分析手术状态（减压与非减压）、孤独感（高与低）和残疾（高与低）作为自变量，生物标志物变量作为因变量的方差分析发现，孤独感与更高水平的皮质醇相关，F(1, 37) = 4.91, p =.04, η =.11，以及更低水平的雌激素，F(1, 36) = 7.29, p =.01, η =.17，但仅在减压患者中。结果强调了孤独感对生物应激反应的可能影响，以及需要对有症状的 CMI 患者进行干预以减少孤独感。
