Bertoni-Freddari C
Gerontological Research Department, INRCA, Ancona, Italy.
Med Hypotheses. 1988 Mar;25(3):147-9. doi: 10.1016/0306-9877(88)90052-7.
Senile dementia of the Alzheimer's type (SDAT) is considered either a specific pathological condition unrelated to normal aging or an accumulation of brain aging alterations leading to clinical dysfunction. In the present paper a hypothesis is formulated to reconcile these two issues to a common denominator, i.e. the increased age-dependent deterioration of the neuronal membrane. If this holds true, normal aging and SDAT may be considered as two different aspects of the same problem and specific interventions to slow down the former can delay the onset of the latter to older ages.
阿尔茨海默型老年痴呆症（SDAT）被认为要么是一种与正常衰老无关的特定病理状况，要么是导致临床功能障碍的脑衰老改变的积累。在本文中，提出了一个假设，以将这两个问题统一到一个共同的因素上，即神经元膜随年龄增长而加剧的退化。如果这一假设成立，那么正常衰老和SDAT可被视为同一问题的两个不同方面，减缓前者的特定干预措施可以将后者的发病推迟到更高龄阶段。
