The value of alternative morphological approaches to Alzheimer's disease.

Coleman and Flood find the morphometric approach of limited value in differentiating the pathological changes in Alzheimer's disease from normal aging. However, other morphological approaches, particularly studies of the chemical neuroanatomy of Alzheimer's disease, are proving to be highly informative. Coleman and Flood's conclusion, that morphological examination of post-mortem brain is of limited value, is not justified.