Saper C B
Department of Pharmacological and Physiological Sciences, University of Chicago, Il 60637.
Neurobiol Aging. 1987 Nov-Dec;8(6):576-7. doi: 10.1016/0197-4580(87)90142-4.
Coleman and Flood find the morphometric approach of limited value in differentiating the pathological changes in Alzheimer's disease from normal aging. However, other morphological approaches, particularly studies of the chemical neuroanatomy of Alzheimer's disease, are proving to be highly informative. Coleman and Flood's conclusion, that morphological examination of post-mortem brain is of limited value, is not justified.
科尔曼和弗拉德发现形态测量方法在区分阿尔茨海默病的病理变化与正常衰老方面价值有限。然而，其他形态学方法，尤其是对阿尔茨海默病化学神经解剖学的研究，正被证明具有很高的信息量。科尔曼和弗拉德认为死后大脑形态学检查价值有限的结论是不合理的。
