School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Nat Prod Res. 2022 Mar;36(6):1515-1521. doi: 10.1080/14786419.2021.1894562. Epub 2021 Mar 7.
Ait. has been utilized as an anticarcinogen, antibacterial and insecticide. Two new prenylflavonoids, Sophoflavonoid A () and Sophoflavonoid B (), together with four known analogues were isolated from the root bark of . The structures of these compounds were elucidated by the interpretation of spectroscopic data and chemical evidence. Their absolute configurations were determined by ECD analysis. The inhibitory effects of compounds against three lung carcinoma cells were determined using the MTT assay. The results revealed that compound displayed strong cytotoxic effect against H460 cell line (IC, 4.67 μM), while compounds , exhibited significant inhibitory effects against three tumor cells. Therefore, this study suggests that the isopentenyl flavonoid-rich products of including the new compounds, could be valuable candidates for the development of pharmaceuticals in the prevention and treatment for tumors.
艾特。已被用作抗癌、抗菌和杀虫剂。从。中分离得到两种新的prenylflavonoids，Sophoflavonoid A () 和 Sophoflavonoid B ( )，以及四种已知类似物。这些化合物的结构通过光谱数据分析和化学证据的解释来阐明。它们的绝对构型通过 ECD 分析确定。采用 MTT 法测定化合物对三种肺癌细胞的抑制作用。结果表明，化合物对 H460 细胞系显示出强烈的细胞毒性作用（IC，4.67 μM），而化合物对三种肿瘤细胞均表现出显著的抑制作用。因此，本研究表明，富含异戊烯基黄酮的 产物，包括新化合物，可能是预防和治疗肿瘤的药物开发的有价值的候选物。
