School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Nat Prod Res. 2022 Jan;36(1):108-113. doi: 10.1080/14786419.2020.1765340. Epub 2020 May 14.
A chemical investigation of Ait. identified 6 compounds. On the basis of spectroscopic data, they were determined to be flavonoids and their analogues, among which were two previously undescribed compounds, sophoflavanone G () and sophoflavanone H (). The inhibitory effects of new compounds against five human tumour cell lines were evaluated in vitro by MTT assays, which revealed potential inhibitory effects with IC values < 20 mM, in particular, compound has shown significant cytotoxicity for several tumour cells with IC values around 20 mM, which was similar to cisplatin and potential to be used as tumour drugs.
对艾氏菊属植物的化学成分研究鉴定了 6 种化合物。根据光谱数据，它们被确定为类黄酮及其类似物，其中包括两种以前未描述的化合物， sophoflavanone G () 和 sophoflavanone H ()。通过 MTT 法测定新化合物对 5 个人类肿瘤细胞系的体外抑制作用，结果表明，具有 IC 值 < 20 mM 的潜在抑制作用，特别是化合物 对几种肿瘤细胞具有显著的细胞毒性，IC 值约为 20 mM，与顺铂相当，具有作为肿瘤药物的潜力。
