Shenzhen Center for Chronic Disease Control, Shenzhen Guangdong 518020.
Xiangya School of Public Health, Central South University, Changsha 410078, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jan 28;46(1):91-97. doi: 10.11817/j.issn.1672-7347.2021.190280.
The causes for male sexual orientation are complicated, which have not yet been clarified. Recent years have witnessed fruitful progress in the field of biology, while the impact of environment has received little attention. Adverse childhood experiences (ACEs), identified as a special environment in the early stage of development, can affect the individual phenotype by DNA methylation. Given the relationships among male sexual orientation, ACEs, and DNA methylation, as well as based on the existing theory, this article proposes the model "ACEs-DNA methylation-male sexual orientation"from the perspective of environment and epigenetics, aiming to provide a theoretical basis for future research.
男性性取向的原因很复杂，尚未阐明。近年来，生物学领域取得了丰硕的进展，而环境的影响却很少受到关注。不良的童年经历（ACEs），被认为是发育早期的一种特殊环境，可以通过 DNA 甲基化影响个体表型。鉴于男性性取向、ACEs 和 DNA 甲基化之间的关系，以及基于现有理论，本文从环境和表观遗传学的角度提出了“ACEs-DNA 甲基化-男性性取向”模型，旨在为未来的研究提供理论基础。
