Adams Steven H
College of Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Proc (Bayl Univ Med Cent). 2020 Oct 29;34(2):250-259. doi: 10.1080/08998280.2020.1836712.
In this descriptive epidemiological study, the soil-transmitted helminth (STH) burden and pancreatic cancer (PC) mortality rates of different countries and peoples are compared to demonstrate an inverse correlation. Formerly ubiquitous helminth infection possibly played a significant role in defending the human host against PC until the advancement of modern hygiene, with helminth eradication in recent times in developed countries and urban centers. It is posited that a high rate of infection by STH in developing countries and rural areas protects the human host from the development of PC, possibly by immune modulation. This hypothesis is used to explain increased PC rates in minority groups in the United States who had decreased helminth exposure in the late 20th century.
在这项描述性流行病学研究中，对不同国家和人群的土源性蠕虫（STH）负担及胰腺癌（PC）死亡率进行比较，以证明两者呈负相关。在现代卫生条件改善之前，曾经普遍存在的蠕虫感染可能在保护人类宿主抵御胰腺癌方面发挥了重要作用，发达国家和城市中心近年来已根除蠕虫。据推测，发展中国家和农村地区较高的STH感染率可能通过免疫调节保护人类宿主免受PC的侵害。这一假设被用来解释20世纪后期蠕虫接触减少的美国少数群体中PC发病率上升的现象。
