Shakeel Sadia, Ahmad Hassali Mohamed Azmi
Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan.
Malays J Med Sci. 2021 Feb;28(1):109-116. doi: 10.21315/mjms2021.28.1.14. Epub 2021 Feb 24.
With the continuation of the second wave of a novel coronavirus disease (COVID-19), which is likely to be even more devastating, there are several associated health problems. COVID-19 is usually mild and non-fatal in children. However, in rare cases, children could severely be affected, and clinical manifestations may differ from adults. A multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication associated with COVID-19, initiated by an overactive immune response in kids that usually hits weeks after exposure to the COVID-19. MIS-C is a disorder in which inflammation could occur in different parts of the body. The disease puts pressure on the heart, as blood vessels leading towards the heart get inflamed and incapable of carrying adequate blood, hence producing cardiac complications in children hospitalised with MIS-C. The problem seems to be associated with COVID-19 in children; however, the association between MIS-C and COVID-19 is still unidentified. There is very little understanding of what triggers the MIS-C, which necessitates a rigorous mapping of the disease and associated risk elements for better disease management and navigating through this crisis.
随着新型冠状病毒肺炎（COVID-19）第二波疫情的持续，其可能造成更大的破坏，还出现了一些相关的健康问题。COVID-19在儿童中通常症状较轻且不致命。然而，在极少数情况下，儿童可能会受到严重影响，其临床表现可能与成人不同。儿童多系统炎症综合征（MIS-C）是一种与COVID-19相关的罕见但严重的并发症，由儿童过度活跃的免疫反应引发，通常在接触COVID-19数周后出现。MIS-C是一种炎症可能发生在身体不同部位的病症。该疾病会给心脏带来压力，因为通向心脏的血管会发炎，无法输送足够的血液，从而导致患有MIS-C的住院儿童出现心脏并发症。这个问题似乎与儿童感染COVID-19有关；然而，MIS-C与COVID-19之间的关联仍不明确。对于引发MIS-C的原因知之甚少，这就需要对该疾病及其相关风险因素进行严格梳理，以便更好地管理疾病并应对这场危机。
