The Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Front Endocrinol (Lausanne). 2021 Feb 19;11:613606. doi: 10.3389/fendo.2020.613606. eCollection 2020.
Maintenance of adipocyte precursors is critical for regulating metabolism and preventing obesity related disease. These precursors have been immortalized and studied in cellular models as well as-more recently-in animal models. However, little is known about adipocyte precursors from animals of different ages. Most research has focused on adipocyte precursors during obesity. This review goes over the most recent reports of adipocyte precursors during development and in adulthood. Some of these new analyses are due to new techniques such as single cell-RNA sequencing and temporally controlled lineage tracing. With these tools, we have been able to further our understanding of adipocyte precursor lineages and their different regulatory mechanisms. As we learn more about adipocyte precursor plasticity and regulation, we can hope to use this knowledge for future clinical applications.
维持脂肪细胞前体细胞对于调节代谢和预防肥胖相关疾病至关重要。这些前体细胞已在细胞模型中被永生化并进行了研究，最近也在动物模型中进行了研究。然而，对于不同年龄动物的脂肪细胞前体细胞知之甚少。大多数研究都集中在肥胖期间的脂肪细胞前体细胞上。本综述回顾了发育中和成年期脂肪细胞前体细胞的最新报道。这些新的分析中有一些是由于新技术的出现，如单细胞 RNA 测序和时间控制的谱系追踪。有了这些工具，我们能够进一步了解脂肪细胞前体细胞的谱系及其不同的调节机制。随着我们对脂肪细胞前体细胞可塑性和调节的了解不断增加，我们有望将这些知识应用于未来的临床应用。
