Laboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Towada, Japan.
Laboratory of Small Animal Internal Medicine 2, School of Veterinary Medicine, Kitasato University, Towada, Japan.
Front Immunol. 2021 Feb 17;11:626295. doi: 10.3389/fimmu.2020.626295. eCollection 2020.
In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the present study, we verified the impact of hydrogen gas treatment in transplantation with the optimal immunosuppressive protocol based on human clinical setting by using the miniature pig model. Marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal vasculitis. We concluded that marginal kidney graft from donor after cardiac death is an acceptable model for chronic rejection and that if the transplantation is carried out using a strict immunosuppressive protocol, chronic rejection may be alleviated even with the marginal kidney.
在临床肾移植中，已知边缘供体肾脏比活体供体更容易发生慢性同种异体排斥反应。在我们之前的研究中，我们使用临床前小型猪模型报告了含氢器官保存液可预防心脏死亡后供体肾脏发生急性损伤。在本研究中，我们使用小型猪模型，根据人类临床情况，通过使用最佳免疫抑制方案，验证了氢气处理在移植中的影响。经过含氢保存液处理的边缘肾脏已进行了长期（超过 100 天）移植。少数病例显示出慢性排斥反应；然而，大多数情况下并未发现慢性排斥反应，如移植物组织纤维化或肾血管炎。我们得出结论，来自心脏死亡供体的边缘供体肾脏移植物是慢性排斥反应的可接受模型，如果使用严格的免疫抑制方案进行移植，即使是边缘肾脏，慢性排斥反应也可能得到缓解。
