Obara Takafumi, Naito Hiromichi, Nojima Tsuyoshi, Hirayama Takahiro, Hongo Takashi, Ageta Kohei, Aokage Toshiyuki, Hisamura Masaki, Yumoto Tetsuya, Nakao Atsunori
Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Biomedicines. 2024 Jan 6;12(1):118. doi: 10.3390/biomedicines12010118.
Hydrogen gas, renowned for its antioxidant properties, has emerged as a novel therapeutic agent with applications across various medical domains, positioning it as a potential adjunct therapy in transplantation. Beyond its antioxidative properties, hydrogen also exerts anti-inflammatory effects by modulating pro-inflammatory cytokines and signaling pathways. Furthermore, hydrogen's capacity to activate cytoprotective pathways bolsters cellular resilience against stressors. In recent decades, significant advancements have been made in the critical medical procedure of transplantation. However, persistent challenges such as ischemia-reperfusion injury (IRI) and graft rejection continue to hinder transplant success rates. This comprehensive review explores the potential applications and therapeutic implications of hydrogen in transplantation, shedding light on its role in mitigating IRI, improving graft survival, and modulating immune responses. Through a meticulous analysis encompassing both preclinical and clinical studies, we aim to provide valuable insights into the promising utility of hydrogen as a complementary therapy in transplantation.
氢气以其抗氧化特性而闻名，已成为一种新型治疗剂，在各个医学领域都有应用，使其成为移植领域潜在的辅助治疗方法。除了抗氧化特性外，氢气还通过调节促炎细胞因子和信号通路发挥抗炎作用。此外，氢气激活细胞保护通路的能力增强了细胞对压力源的抵抗力。近几十年来，移植这一关键医疗程序取得了重大进展。然而，诸如缺血再灌注损伤（IRI）和移植物排斥等持续挑战仍然阻碍着移植成功率。这篇综述探讨了氢气在移植中的潜在应用和治疗意义，阐明了其在减轻IRI、提高移植物存活率和调节免疫反应方面的作用。通过对临床前和临床研究的细致分析，我们旨在为氢气作为移植辅助治疗的前景提供有价值的见解。
