Liu Bingyang, Li Yue, Guo Jiamei, Fan Yuting, Li Ling, Li Ping
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110022, China.
Department of Endocrinology, Tianjin Third Central Hospital, Tianjin, China.
Int J Endocrinol. 2021 Feb 18;2021:8888862. doi: 10.1155/2021/8888862. eCollection 2021.
To investigate the influence of body mass index (BMI) and its change from adolescence to adulthood (ΔBMI) on the risk of metabolic syndrome (MetS) in early adulthood.
We selected 931 students from 12 to 16 years of age in Liaoyang City, China. Ninety-three participants from 18 to 22 years of age with complete baseline data were available for follow-up after 5 years. Statistical analysis determined the relationship of MetS at follow-up with baseline BMI (BMI), ΔBMI, and follow-up BMI (BMI).
ΔBMI was positively correlated with the change of waist circumference (ΔWC), systolic blood pressure (ΔSBP), triglycerides (ΔTG), uric acid, and glycosylated hemoglobin (ΔHbA1c) in follow-up ( < 0.05). For every 1 kg/m increase in BMI, ΔBMI, and BMI the risk of MetS at follow-up increased 1.201-fold, 1.406-fold, and 1.579-fold, respectively. Both BMI and ΔBMI were predictive of MetS at follow-up, with prediction thresholds of 23.47 kg/m and 1.95 kg/m. The participants were divided by the predicted BMI and ΔBMI threshold values into four study groups. Interestingly, the group with lower BMI but a higher increase in BMI presented the same metabolic derangements and Mets% of the group with higher BMI but lower Δ BMI.
Both BMI of adolescence and ΔBMI were predictive of MetS and cardiovascular risk factors in adulthood. Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.
探讨体重指数（BMI）及其从青少年期到成年期的变化（ΔBMI）对成年早期代谢综合征（MetS）风险的影响。
我们选取了中国辽阳市931名12至16岁的学生。5年后，93名18至22岁且有完整基线数据的参与者可供随访。统计分析确定了随访时MetS与基线BMI（BMI）、ΔBMI和随访BMI（BMI）之间的关系。
随访时，ΔBMI与腰围变化（ΔWC）、收缩压（ΔSBP）、甘油三酯（ΔTG）、尿酸和糖化血红蛋白（ΔHbA1c）呈正相关（<0.05）。BMI、ΔBMI和BMI每增加1 kg/m²，随访时MetS的风险分别增加1.201倍、1.406倍和1.579倍。BMI和ΔBMI均为随访时MetS的预测指标，预测阈值分别为23.47 kg/m²和1.95 kg/m²。根据预测的BMI和ΔBMI阈值将参与者分为四个研究组。有趣的是，BMI较低但BMI增加较高的组与BMI较高但ΔBMI较低的组呈现出相同的代谢紊乱和MetS百分比。
青少年期的BMI和ΔBMI均为成年期MetS和心血管危险因素的预测指标。与单独控制BMI相比，同时控制青少年的这两个变量在降低年轻成年人MetS风险方面将更有效。
