中药对缺血再灌注损伤后的肾保护作用及潜在机制
Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury.
作者信息
Liu Demin, Tang Songling, Gan Lu, Cui Wei
机构信息
Cardiology Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Research Laboratory of Emergency Medicine, Department of Emergency Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Evid Based Complement Alternat Med. 2021 Feb 19;2021:5579327. doi: 10.1155/2021/5579327. eCollection 2021.
Abstract
Renal ischemia-reperfusion (I/R) injury mainly causes acute kidney injury (AKI) after renal transplantation, trauma, sepsis, and hypovolemic shock. Patients with renal I/R injury are frequently associated with a poor prognosis. Traditional Chinese medicine (TCM) has been used for the prevention and treatment of various diseases in China and other Asian countries for centuries. Many studies have shown the protective effect of TCM on renal I/R injury, due to its diverse bioactive components. The potential mechanisms of TCMs on renal I/R injury include anti-inflammation, antioxidative effect, anti-cell death, downregulation of adhesion molecule expression, regulation of energy metabolism by restoring Na-K-ATPase activity, and mitochondrial fission. This review summarizes the major developments in the effects and underlying mechanisms of TCMs on the renal I/R injury.
摘要
肾缺血再灌注（I/R）损伤主要导致肾移植、创伤、脓毒症和低血容量性休克后发生急性肾损伤（AKI）。肾I/R损伤患者的预后往往较差。几个世纪以来，中医在中国和其他亚洲国家一直被用于预防和治疗各种疾病。许多研究表明，由于其多样的生物活性成分，中药对肾I/R损伤具有保护作用。中药对肾I/R损伤的潜在机制包括抗炎、抗氧化作用、抗细胞死亡、下调黏附分子表达、通过恢复钠钾ATP酶活性调节能量代谢以及线粒体分裂。本综述总结了中药对肾I/R损伤的作用及其潜在机制的主要进展。
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本文引用的文献
1
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Mediators Inflamm. 2020 Nov 24;2020:8869511. doi: 10.1155/2020/8869511. eCollection 2020.
2
Sanqi Oral Solution Ameliorates Renal Ischemia/Reperfusion Injury via Reducing Apoptosis and Enhancing Autophagy: Involvement of ERK/mTOR Pathways.
Front Pharmacol. 2020 Sep 16;11:537147. doi: 10.3389/fphar.2020.537147. eCollection 2020.
3
Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury Nrf2 Pathway.
Front Pharmacol. 2020 Sep 3;11:541426. doi: 10.3389/fphar.2020.541426. eCollection 2020.
4
[Study on therapeutic effect and its related mechanism of anemoside B4 on ischemia reperfusion injury induced by renal artery and vein ligation in rats].
Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(3):617-622. doi: 10.19540/j.cnki.cjcmm.20191209.401.
5
Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress.
Acta Biochim Biophys Sin (Shanghai). 2020 Feb 3;52(2):125-132. doi: 10.1093/abbs/gmz145.
6
Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling.
Int J Mol Sci. 2019 Dec 12;20(24):6280. doi: 10.3390/ijms20246280.
7
Protective effects of polydatin on multiple organ ischemia-reperfusion injury.
Bioorg Chem. 2020 Jan;94:103485. doi: 10.1016/j.bioorg.2019.103485. Epub 2019 Dec 4.
8
Cryptotanshinone ameliorates renal ischaemia-reperfusion injury by inhibiting apoptosis and inflammatory response.
Basic Clin Pharmacol Toxicol. 2019 Nov;125(5):420-429. doi: 10.1111/bcpt.13275. Epub 2019 Jul 22.
9
Protective effect of hyperoside against renal ischemia-reperfusion injury modulating mitochondrial fission, oxidative stress, and apoptosis.
Free Radic Res. 2019 Jul;53(7):727-736. doi: 10.1080/10715762.2019.1623883. Epub 2019 Jun 11.
10
Protective effect of hydroxysafflor yellow A against acute kidney injury via the TLR4/NF-κB signaling pathway.
Sci Rep. 2018 Jun 15;8(1):9173. doi: 10.1038/s41598-018-27217-3.
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