Ma Wen, Tang Songling, Xie Dina, Gu Guoqiang, Gan Lu
Sichuan University-The Hong Kong Polytechnic University Institute for Disaster Management and Reconstruction, Chengdu 610207, China.
Research Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Evid Based Complement Alternat Med. 2021 Apr 8;2021:5564401. doi: 10.1155/2021/5564401. eCollection 2021.
Liver ischemia-reperfusion (I/R) injury occurs during transplantation and major hepatic surgery, which may lead to postoperative liver dysfunction. More and more traditional Chinese medicines (TCMs) have been used to treat liver ischemia-reperfusion injury. The purpose of this review is to evaluate the different protective effects of TCMs in the treatment of liver ischemia-reperfusion injury and to summarize its possible mechanisms. The results indicate that TCMs attenuate liver I/R injury via multiple mechanisms, including antioxidation stress, anti-inflammatory response, antiapoptosis, and inhibiting endoplasmic reticulum stress. However, the in-depth mechanism of the protective effects of these traditional Chinese medicines still remains unknown.
肝缺血再灌注（I/R）损伤发生于肝移植和大型肝脏手术过程中，这可能导致术后肝功能障碍。越来越多的中药被用于治疗肝缺血再灌注损伤。本综述的目的是评估中药在治疗肝缺血再灌注损伤中的不同保护作用，并总结其可能的机制。结果表明，中药通过多种机制减轻肝I/R损伤，包括抗氧化应激、抗炎反应、抗凋亡以及抑制内质网应激。然而，这些中药保护作用的深入机制仍不清楚。
