Egido-Moreno Sonia, Valls-Roca-Umbert Joan, Jané-Salas Enric, López-López José, Estrugo-Devesa Albert
DDS. Professor of Oral Pathology. Department of Odontostomatology. Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona. University Campus of Bellvitge, Barcelona, Spain.
DDS, Professor of Master's degree, School of Dentistry, University of Barcelona. University Campus of Bellvitge, Barcelona, Spain.
J Clin Exp Dent. 2021 Mar 1;13(3):e287-e294. doi: 10.4317/jced.57981. eCollection 2021 Mar.
BACKGROUND: The COVID-19 disease first appeared in December 2019 in Wuhan, China. The World Health Organization (WHO) declared the pandemic in March 2020, with 40 million cases and a million deaths in October 2020. COVID-19 also includes manifestations on the skin and mucous mucosal membrane. Objective: To evaluate the prevalence of the oral lesions associated to COVID-19 disease; and evaluate their clinical presentation and the hypothesized etiology. MATERIAL AND METHODS: An electronic literature search was performed in PubMed, Scopus and Índice Médico Español databases. The following combination of keywords and Boolean operators were used: "COVID-19 AND oral manifestations"; "COVID-19 AND oral lesions"; "COVID-19 AND mucosal lesions" ; "COVID-19 AND mucosal manifestations"; "SARS-COV-2 AND oral manifestations"; "SARS-COV-2 AND oral lesions"; "SARS-COV-2 AND mucosal lesions"; "SARS-COV-2 AND mucosal manifestations". Furthermore, the bibliography was reviewed to manually include additional articles. The risk of bias in individual studies was assessed by two blinded reviewers using the Joanna Briggs Institute (JBI) and the evidence levels of the articles found will be cataloged according to the level of evidence and grade of recommendation of Oxford Centre for Evidence-Based Medicine (CEBM). RESULTS: 249 articles were found in the Medline / Pubmed database. There are no additional articles in the Scopus and Índice Médico Español databases. We selected 14 articles plus 5 more articles due to manual searching. Patients presented a wide variety of oral manifestations. The most prevalent were lesions with a solution of continuity (n = 48, 73.85%) and the most frequent area was the tongue (n = 41, 52.56%). The preferred treatment for the lesions is a localized one by using rinses. CONCLUSIONS: To conclude, after the bibliographic review was performed, we can expect that the COVID-19 disease can cause cutaneous and mucosal lesions as secondary manifestations. Despite more studies being needed to confirm this. COVID-19, SARS-COV-2, oral lesions, oral manifestations.
背景：2019年12月，新型冠状病毒肺炎（COVID-19）首次在中国武汉出现。2020年3月，世界卫生组织宣布该疾病大流行，到2020年10月已有4000万例病例和100万人死亡。COVID-19还包括皮肤和黏膜的表现。目的：评估与COVID-19疾病相关的口腔病变的患病率；并评估其临床表现及推测的病因。 材料与方法：在PubMed、Scopus和西班牙医学索引数据库中进行电子文献检索。使用了以下关键词和布尔运算符的组合：“COVID-19与口腔表现”；“COVID-19与口腔病变”；“COVID-19与黏膜病变”；“COVID-19与黏膜表现”；“严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与口腔表现”；“SARS-CoV-2与口腔病变”；“SARS-CoV-2与黏膜病变”；“SARS-CoV-2与黏膜表现”。此外，还查阅了参考文献以手动纳入其他文章。由两名盲法评审员使用乔安娜·布里格斯研究所（JBI）评估个体研究中的偏倚风险，所发现文章的证据水平将根据牛津循证医学中心（CEBM）的证据水平和推荐等级进行分类。 结果：在Medline/Pubmed数据库中发现249篇文章。Scopus和西班牙医学索引数据库中没有其他文章。通过手动检索，我们又选择了14篇文章以及另外5篇文章。患者表现出多种多样的口腔表现。最常见的是连续性中断的病变（n = 48，73.85%），最常出现病变的部位是舌头（n = 41，52.56%）。病变的首选治疗方法是使用漱口水进行局部治疗。 结论：总之，在进行文献综述后，我们可以预期COVID-19疾病可导致皮肤和黏膜病变作为继发表现。尽管还需要更多研究来证实这一点。COVID-19、SARS-CoV-2、口腔病变、口腔表现。
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