Cruz Tapia Roberto Onner, Peraza Labrador Alberto Jose, Guimaraes Douglas Magno, Matos Valdez Luciano Hermios
Department of Oral and Maxillofacial Pathology, Postgraduate and Research Division, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Department of Oral and Maxillofacial Pathology, Universidad El Bosque, Bogota, Colombia.
Spec Care Dentist. 2020 Nov;40(6):555-560. doi: 10.1111/scd.12520. Epub 2020 Sep 3.
Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS-CoV-2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection.
To describe the clinico-pathological oral mucosal lesions in four patients with confirmed SARS-CoV-2 infection.
Four patients with COVID-19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica-like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID-19 was established.
Infection with SARS-CoV-2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long-term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID-19 disease.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染呈阳性的患者中曾有口腔黏膜出现水疱大疱性和斑疹性病变的报道。尽管如此，在感染的临床进展或结局中，口腔表现的意义和病理生理学尚未明确。
描述4例确诊为SARS-CoV-2感染患者的临床病理口腔黏膜病变。
4例经聚合酶链反应（PCR）确诊的新型冠状病毒肺炎患者出现了出血性大疱性口炎样病变、血管病变和非特异性口炎，1例患者的组织学分析显示血管周围反应性淋巴细胞浸润、局灶性毛细血管血栓形成和出血。根据对其他局部和全身状况的鉴别以及口腔和全身症状的同时出现，确立了可能与新型冠状病毒肺炎相关的口腔病变诊断。
SARS-CoV-2感染可能导致具有多种临床表现的口腔表现，这大概支持血栓形成和血管炎的假说；然而，这些发现需要更多证据以及对患者进行长期随访，以准确确立口腔黏膜病变在新型冠状病毒肺炎疾病中的意义。
