Kot Wai Ying, Li Jing Wen, Chan Alice Kit Ying, Zheng Li Wu
Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Division of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Oral Health. 2023 Dec 18;4:1322458. doi: 10.3389/froh.2023.1322458. eCollection 2023.
The aim of this systematic review is to provide a clinical update of the current knowledge on COVID-19 and oral mucosal lesions, to analyze the types and prevalence of oral mucosal lesions in patients with COVID-19, and to clarify the potential association between COVID-19 and oral mucosal lesions.
The literature search was conducted using PubMed, Web of Science, Scopus and the Cochrane Library, as well as literatures via manual searches of the reference lists of included studies. Studies published in English that mentioned oral mucosal lesions in patients with COVID-19 were included, resulting in a total of 31 studies.
Most of the included studies were considered to have a moderate to high risk of bias according to the Joanna Briggs Institute bias assessment tools. Based on COVID-19 severity, the characteristics and patterns of oral mucosal lesions in COVID-19 patients were described, analyzed and synthesized. Overall, ulcers without specific diagnosis had the highest prevalence in COVID-19 patients, followed by traumatic ulcers, candidiasis, petechiae and aphthous-like lesions. Homogeneity of data cannot be achieved in statical analysis, indicating randomness of outcome (ulcers without specific diagnosis, 95% CI: 28%-96%, = 98.7%).
Given the limited evidence from currently available studies, the association between COVID-19 and oral mucosal lesions remains difficult to clarify. Healthcare professionals should be aware of the possible association between COVID-19 and oral mucosal lesions, and we hereby discuss our findings.
本系统评价的目的是提供关于新型冠状病毒肺炎（COVID-19）和口腔黏膜病变的当前知识的临床更新，分析COVID-19患者口腔黏膜病变的类型和患病率，并阐明COVID-19与口腔黏膜病变之间的潜在关联。
使用PubMed、科学网、Scopus和考克兰图书馆进行文献检索，并通过人工检索纳入研究的参考文献列表来获取文献。纳入了以英文发表的提及COVID-19患者口腔黏膜病变的研究，共31项研究。
根据乔安娜·布里格斯研究所的偏倚评估工具，大多数纳入研究被认为存在中度至高度偏倚风险。根据COVID-19的严重程度，对COVID-19患者口腔黏膜病变的特征和模式进行了描述、分析和综合。总体而言，未明确诊断的溃疡在COVID-19患者中患病率最高，其次是创伤性溃疡、念珠菌病、瘀点和类阿弗他病变。在统计分析中无法实现数据的同质性，表明结果具有随机性（未明确诊断的溃疡，95%置信区间：28%-96%，I² = 98.7%）。
鉴于目前现有研究的证据有限，COVID-19与口腔黏膜病变之间的关联仍难以阐明。医疗保健专业人员应意识到COVID-19与口腔黏膜病变之间可能存在的关联，我们在此讨论我们的研究结果。
