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误服重复负荷剂量的地加瑞克导致急性精神病。

Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis.

作者信息

Hamdoon Musaab, Satchi Maria, Fawke Fay, Madaan Sanjeev

机构信息

Department of Urology, Darent Valley Hospital, Dartford DA2 8DA, UK.

出版信息

JRSM Open. 2021 Feb 19;12(2):2054270420983105. doi: 10.1177/2054270420983105. eCollection 2021 Feb.

Abstract

Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix.

摘要

晚期和转移性前列腺癌通常采用激素阻断治疗。促黄体生成素释放激素拮抗剂可迅速抑制睾酮,用于治疗晚期或转移性前列腺癌。地加瑞克是一种促黄体生成素释放激素拮抗剂,给药时先给予负荷剂量,随后每月给予维持剂量。我们报告了一例患者意外接受了第二剂地加瑞克负荷剂量,导致出现急性精神病症状,表现为惊恐发作、妄想、自杀念头、失眠以及一些视幻觉,而这些症状并未被报告为地加瑞克的副作用。

相似文献

6
Degarelix: a new approach for the treatment of prostate cancer.地加瑞克:前列腺癌治疗的新方法。
Neuroendocrinology. 2009;90(3):235-44. doi: 10.1159/000228832. Epub 2009 Jul 14.

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