Samreen Fnu, Popal Ubaidullah, Qutrio Baloch Zulfiqar A
Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
Internal Medicine, Tabba Heart Institute, Karachi, PAK.
Cureus. 2021 Feb 1;13(2):e13054. doi: 10.7759/cureus.13054.
Misuse of androgenic-anabolic steroids (AAS) has been well known to increase the risk for a cardiac problem, including acute myocardial infarction (MI). Steroids once thought a magic drug providing immediate relief to patients, also have a darker aspect of its severe side effects. AAS are widely used these days, especially in teenagers, bodybuilders, and athletes. MI is thought to be a disease of old age, but young patients with MI without risk factors draw attention to the possibility of drugs such as cocaine, AAS abuse, and amphetamine. In this article, we report the case of a 38-year-old African-American male, with a history of AAS abuse, who arrived at the emergency department with complaints of severe chest pain radiating to the left arm. An electrocardiogram (ECG) revealed ST-elevation MI (STEMI) and elevated troponin. The patient was transferred to the cardiac catheterization lab for an emergent catheterization which showed 100% stenosis of the left anterior descending artery and a drug-eluting stent was placed. An echocardiogram showed an ejection fraction of 35%. All blood workup was negative. The patient was discharged on aspirin, ticagrelor, statin, ACE inhibitor, and B-blocker after three days. Chest pain in a young patient population secondary to MI is not uncommon these days and the most important thing to evaluate is drug history, including AAS use. Athletes, bodybuilders, and others who use steroids or other drugs that are responsible for MI should be under the supervision of physicians so that the complications of steroids are ascertained, and if steroids are needed for any medical illness, proper dosage and follow-up should be emphasized. Therefore, while taking history from a patient, it is essential for physicians to be aware of this association of steroids with coronary artery disease.
滥用雄激素类合成代谢类固醇(AAS)会增加患心脏问题的风险,包括急性心肌梗死(MI),这一点已广为人知。类固醇曾被认为是能为患者带来即时缓解的神奇药物,但它也有严重副作用这一阴暗面。如今AAS被广泛使用,尤其是在青少年、健美运动员和运动员中。MI通常被认为是一种老年疾病,但无风险因素的年轻MI患者让人们注意到可卡因、AAS滥用和安非他命等药物的可能性。在本文中,我们报告了一名38岁有AAS滥用史的非裔美国男性病例,他因严重胸痛放射至左臂而到急诊科就诊。心电图(ECG)显示ST段抬高型心肌梗死(STEMI)且肌钙蛋白升高。患者被转至心脏导管实验室进行紧急导管插入术,结果显示左前降支动脉100%狭窄,并置入了药物洗脱支架。超声心动图显示射血分数为35%。所有血液检查结果均为阴性。三天后,患者出院时服用阿司匹林、替格瑞洛、他汀类药物、血管紧张素转换酶抑制剂和β受体阻滞剂。如今,年轻患者群体中因MI继发胸痛的情况并不少见,而最重要的评估内容是用药史,包括AAS的使用情况。运动员、健美运动员和其他使用类固醇或其他导致MI的药物的人应在医生的监督下,以便确定类固醇的并发症,并且如果因任何医疗疾病需要使用类固醇,应强调适当的剂量和随访。因此,在询问患者病史时,医生必须了解类固醇与冠状动脉疾病之间的这种关联。