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来自新冠病毒疾病死亡供体的肾移植

Kidney transplantation from COVID-19 deceased donor.

作者信息

Perlin DmitryV, Shmanev ArtemO, Perlina AnastasiaD, Kulikov PavelA

机构信息

Volgograd Regional Center of Urology and Nephrology, Volzhsky, Russia.

出版信息

Urol Case Rep. 2021 Jul;37:101617. doi: 10.1016/j.eucr.2021.101617. Epub 2021 Mar 1.

DOI:10.1016/j.eucr.2021.101617
PMID:33680855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7917438/
Abstract

We present first known case of kidney transplantation from deceased donor who was retrospectively diagnosed with COVID-19. The recipient hadn't febrile and no other symptoms of acute respiratory disease during all hospital stay. No serum anti-SARS-CoV-2 IgM, IgG were detected before and during 6 weeks after surgery. Repeated nasopharyngeal swabs rRT-PCR were negative during all the period. The patient was discharged with normal serum creatinine and doing well with no clinical or laboratory signs of COVID-19 after 8 months. The presented clinical cases demonstrate the possibility of non-transmission of SARS-Cov-2 with renal graft.

摘要

我们报告首例已知的来自一名事后被诊断患有新冠肺炎的已故供体的肾移植病例。在整个住院期间,受者未发热,也没有其他急性呼吸道疾病症状。术前及术后6周内均未检测到血清抗SARS-CoV-2 IgM、IgG。在此期间,多次鼻咽拭子rRT-PCR检测均为阴性。患者出院时血清肌酐正常,8个月后无新冠肺炎的临床或实验室迹象,情况良好。所呈现的临床病例证明了肾移植中SARS-CoV-2不传播的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2849/7935704/80ad93ab69f1/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2849/7935704/80ad93ab69f1/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2849/7935704/80ad93ab69f1/gr1a.jpg

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Curr Transplant Rep. 2021;8(4):281-292. doi: 10.1007/s40472-021-00343-0. Epub 2021 Oct 26.

本文引用的文献

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A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients' Lives and Allografts.肾移植受者中新型冠状病毒肺炎感染的系统评价:保护患者生命和同种异体移植物的共同努力
J Clin Med. 2020 Sep 16;9(9):2986. doi: 10.3390/jcm9092986.
2
Kidney Transplantation in the Times of COVID-19 - A Literature Review.新冠疫情时代的肾移植——文献综述
Ann Transplant. 2020 Jul 24;25:e925755. doi: 10.12659/AOT.925755.
3
Covid-19 and Kidney Transplantation.新冠病毒-19与肾移植
N Engl J Med. 2020 Jun 18;382(25):2475-2477. doi: 10.1056/NEJMc2011117. Epub 2020 Apr 24.
4
Early impact of COVID-19 on transplant center practices and policies in the United States.美国 COVID-19 对移植中心实践和政策的早期影响。
Am J Transplant. 2020 Jul;20(7):1809-1818. doi: 10.1111/ajt.15915. Epub 2020 May 10.
5
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019.识别 2019 冠状病毒疾病的肾移植受者。
Eur Urol. 2020 Jun;77(6):742-747. doi: 10.1016/j.eururo.2020.03.030. Epub 2020 Apr 2.