Redy Keisar Orit, Nahum Victoria, Yehezkel Lea, Marcovitch Itzhak, Columbus Ishay, Fridkin Gil, Chen Ravit
Department of Organic Chemistry, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
ACS Omega. 2021 Feb 16;6(8):5359-5367. doi: 10.1021/acsomega.0c05493. eCollection 2021 Mar 2.
Active gels present unique potential for the decontamination of chemical warfare agents (CWAs) as they strongly adhere to surfaces, thus allowing prolonged decontamination time. Herein, we present a decontamination hydrogel based on polyvinyl alcohol/borax, which contains sodium perborate (NaBO), as an in situ source of the active ingredient hydrogen peroxide. Developed as a binary formulation, this gel instantly forms and effectively sticks when sprayed on various matrices, including porous and vertically positioned matrices. The gel efficiently detoxified the CWAs sarin (GB), -ethyl -2-(diisopropylamino)ethyl methylphosphonothioate (VX), and sulfur mustard (HD) in test tubes (2 μL CWA/0.5 mL gel) to provide nontoxic products with reaction half-lives of <3, 45 and 113 min, respectively. The gel was also shown to efficiently decontaminate surfaces contaminated with VX (5-7 mg, 8-12 mL of gel, i.e., >99%) and to prevent GB evaporation, as proven by laboratory wind tunnel experiments. The universal decontamination abilities of this mild hydrogel, as well as its facile application and removal processes suggest that it holds high potential for future development as a new CWA decontamination tool.
活性凝胶在化学战剂（CWA）去污方面具有独特潜力，因为它们能牢固地附着在表面，从而延长去污时间。在此，我们展示一种基于聚乙烯醇/硼砂的去污水凝胶，其含有过硼酸钠（NaBO）作为活性成分过氧化氢的原位来源。这种凝胶以二元配方开发，喷涂在包括多孔和垂直放置的各种基质上时能立即形成并有效粘附。在试管中（2 μL化学战剂/0.5 mL凝胶），该凝胶能有效解毒化学战剂沙林（GB）、乙基-2-（二异丙基氨基）乙基甲基硫代膦酸酯（VX）和芥子气（HD），分别以<3、45和113分钟的反应半衰期提供无毒产物。实验室风洞实验证明，该凝胶还能有效净化被VX污染的表面（5 - 7毫克，8 - 12毫升凝胶，即>99%）并防止GB蒸发。这种温和水凝胶的通用去污能力，以及其简便的应用和去除过程表明，它作为一种新型化学战剂去污工具具有很高的未来发展潜力。
