Kok R A, Taylor J A, Bradley W L
Dept. of Chemistry, Millikin University, Decatur, IL 62522.
Orig Life Evol Biosph. 1988;18(1-2):135-42. doi: 10.1007/BF01808787.
Steinman and Cole (1967) have claimed that amino acids will naturally assume a nonrandom sequence when polymerized into polypeptides. They based their claim on a comparison of the frequency with which various dipeptide bonds formed in a dilute solution of amino acids to the various depeptide frequencies actually observed in ten proteins. Although the trends in the normalized frequencies go in the same direction, a statistical examination of the two sets of frequencies indicates that there is no correlation at all between experimental dipeptide frequencies and actual depeptide frequencies based on the chi-square tests.
斯坦曼和科尔（1967年）声称，氨基酸在聚合成多肽时会自然呈现出非随机序列。他们的这一说法基于对氨基酸稀溶液中形成的各种二肽键的频率与在十种蛋白质中实际观察到的各种二肽频率进行的比较。尽管归一化频率的趋势是相同的，但对这两组频率的统计检验表明，基于卡方检验，实验二肽频率与实际二肽频率之间根本没有相关性。
