Zhu Lei, Liang Huixin, Lv Fei, Xie Deqiao, Wang Changjiang, Mao Yuyi, Yang Youwen, Tian Zongjun, Shen Lida
College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
Suzhou Yunzhi Medical Technology Company, Ltd., Suzhou 215600, China.
ACS Biomater Sci Eng. 2021 Apr 12;7(4):1663-1672. doi: 10.1021/acsbiomaterials.0c01392. Epub 2021 Mar 8.
An irregular porous structure plays a major role in bone tissue engineering, and it is more suitable for bone tissue growth than a regular porous structure. The response surface method was used to establish a relationship between the average pore size and the design parameters. The technology of selective laser melting was utilized to fabricate the porous Ti-6Al-4V scaffolds with an irregularity of (0.4) and porosities of (70, 80, and 90%) designed using the Voronoi-tessellation method. Compression tests of porous scaffolds showed an elastic modulus range of 0.84-1.97 GPa and an ultimate strength ranging within 21.0-99.1 MPa. The elastic modulus was mainly influenced by the porosity and heat-treatment process. Furthermore, the fatigue test results suggested that the number of cycles (9 × 10 to 1.8 × 10) was greatly influenced by the porosity and heat-treatment process. The heat treatment of annealing greatly improved the fatigue performance of porous scaffolds. The irregular porous scaffolds with lower porosity and after full annealing exhibited the best fatigue behavior.
不规则多孔结构在骨组织工程中起着主要作用,并且它比规则多孔结构更适合骨组织生长。采用响应面法建立了平均孔径与设计参数之间的关系。利用选择性激光熔化技术制造了孔隙率为(70%、80%和90%)且不规则度为(0.4)的多孔Ti-6Al-4V支架,这些支架是使用Voronoi镶嵌法设计的。多孔支架的压缩试验表明,弹性模量范围为0.84-1.97 GPa,极限强度在21.0-99.1 MPa范围内。弹性模量主要受孔隙率和热处理工艺的影响。此外,疲劳试验结果表明,循环次数(9×10至1.8×10)受孔隙率和热处理工艺的影响很大。退火热处理大大提高了多孔支架的疲劳性能。孔隙率较低且经过完全退火的不规则多孔支架表现出最佳的疲劳性能。