HMGB1 表达评估胃癌严重程度的价值：系统荟萃分析。
Value of HMGB1 expression for assessing gastric cancer severity: a systematic meta-analysis.
机构信息
Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
出版信息
J Int Med Res. 2021 Mar;49(3):300060521993312. doi: 10.1177/0300060521993312.
OBJECTIVE
To evaluate the clinical value of high mobility group box-1 (HMGB1) expression levels in patients with gastric cancer.
METHODS
Articles published from January 2000 to August 2022 were searched using PubMed, Google Scholar and Science Direct, Springer, Wiley and NIH to evaluate the clinicopathological significance of HMGB1 expression in gastric cancer.
RESULTS
A total of 156 publications were selected, of which six studies, comprising 846 patients, met the criteria for inclusion in this study. Forest plots of clinicopathological characteristics indicated that HMGB1 expression was not associated with age (odds ratio (OR) = 1.07, 95% confidence interval (CI): 0.89-1.28), sex (OR = 0.90, 95% CI: 0.81-1.00), TNM (OR = 1.39, 95% CI: 0.82-2.37), N stage (OR = 1.42, 95% CI: 0.97-2.07), or tumor differentiation (OR = 0.96, 95% CI: 0.71-1.29), but was highly correlated with pT stage (OR = 1.56, 95% CI: 1.17-2.07). Funnel plots showed no significant publication bias in the included studies in terms of age, sex, TNM, pT stage, N stage, or tumor differentiation.
CONCLUSION
HMGB1 expression was significantly correlated with tumor pT stage, but not with age, sex, TNM stage, tumor N stage, tumor differentiation, or lymphatic metastasis in patients with GC.
目的
评估高迁移率族蛋白 B1（HMGB1）在胃癌患者中的表达水平的临床价值。
方法
通过检索 PubMed、Google Scholar 和 Science Direct、Springer、Wiley 和 NIH，检索 2000 年 1 月至 2022 年 8 月发表的文章，以评估 HMGB1 在胃癌中的表达与临床病理特征的相关性。
结果
共筛选出 156 篇文献，其中 6 项研究（共 846 例患者）符合纳入标准。临床病理特征的森林图表明，HMGB1 的表达与年龄（比值比（OR）=1.07，95%置信区间（CI）：0.89-1.28）、性别（OR=0.90，95%CI：0.81-1.00）、TNM（OR=1.39，95%CI：0.82-2.37）、N 分期（OR=1.42，95%CI：0.97-2.07）或肿瘤分化（OR=0.96，95%CI：0.71-1.29）无关，但与 pT 分期（OR=1.56，95%CI：1.17-2.07）高度相关。漏斗图显示，纳入的研究在年龄、性别、TNM、pT 分期、N 分期或肿瘤分化方面均无显著发表偏倚。
结论
HMGB1 的表达与 GC 患者的肿瘤 pT 分期显著相关，但与年龄、性别、TNM 分期、肿瘤 N 分期、肿瘤分化或淋巴转移无关。
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