Department of Oncology, Guizhou Provincial People's Hospital, Guiyang 550002, China.
Department of Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China.
Dis Markers. 2020 Sep 19;2020:4763492. doi: 10.1155/2020/4763492. eCollection 2020.
Neuropilin 1 (NRP1) is involved in tumorigenesis, development, invasion, and metastasis by promoting angiogenesis of tumors. The study is aimed at evaluating the correlation between the expression of NRP1 protein and clinicopathological features of gastric cancer by meta-analysis.
The published studies were searched in databases including CNKI, Wanfang, Chongqing VIP, Web of Science, and PubMed online. Clinical case studies were included to compare the correlation between NRP1 protein expression and clinicopathological characteristics of gastric cancer. The quality of the included literatures was evaluated by NOS scale. Meta-analysis was performed by Stata software to calculate the odds ratio (OR) and 95% confidence interval (CI).
A total of 12 studies were included in this analysis, involving 1,225 patients with gastric cancer. The analysis indicated that the expression of NRP1 protein in gastric cancer tissues was lower in the group of early stage versus advanced stage (OR = 0.128, 95%CI = 0.059 - 0.277, ≤ 0.001), tumor size less than 5 cm versus more than 5 cm (OR = 0.443, 95%CI = 0.310 - 0.632, ≤ 0.001), TNM stage I-II group versus stage III-IV patients (OR = 0.736, 95%CI = 0.589 - 0.919, = 0.007), well to medium differentiation group versus poor differentiation group (OR = 0.735, 95%CI = 0.632 - 0.854, ≤ 0.001), and nonlymph node metastasis group versus lymph node metastasis group (OR = 0.667, 95%CI = 0.522 - 0.854, ≤ 0.001). The expression of NRP1 protein in gastric cancer was not related to gender, age, and Laurèn's classification.
The expression of NRP1 protein in gastric cancer is closely correlated to clinical stage, tumor size, TNM stage, differentiation, and lymph node metastasis.
神经纤毛蛋白 1（NRP1）通过促进肿瘤血管生成而参与肿瘤的发生、发展、侵袭和转移。本研究旨在通过荟萃分析评估 NRP1 蛋白表达与胃癌临床病理特征的相关性。
在 CNKI、万方、重庆维普、Web of Science 和 PubMed 在线数据库中检索已发表的研究。纳入比较 NRP1 蛋白表达与胃癌临床病理特征相关性的临床病例研究。使用 NOS 量表评估纳入文献的质量。使用 Stata 软件进行荟萃分析，计算比值比（OR）和 95%置信区间（CI）。
本分析共纳入 12 项研究，涉及 1225 例胃癌患者。分析表明，胃癌组织中 NRP1 蛋白的表达在早期与晚期（OR=0.128，95%CI=0.059-0.277， ≤ 0.001）、肿瘤直径小于 5cm 与大于 5cm（OR=0.443，95%CI=0.310-0.632， ≤ 0.001）、TNM Ⅰ-Ⅱ期与Ⅲ-Ⅳ期患者（OR=0.736，95%CI=0.589-0.919， = 0.007）、中高分化组与低分化组（OR=0.735，95%CI=0.632-0.854， ≤ 0.001）、无淋巴结转移组与淋巴结转移组（OR=0.667，95%CI=0.522-0.854， ≤ 0.001）之间存在相关性。NRP1 蛋白在胃癌中的表达与性别、年龄和 Laurèn 分类无关。
NRP1 蛋白在胃癌中的表达与临床分期、肿瘤大小、TNM 分期、分化和淋巴结转移密切相关。
