生殖器感染疫苗：我们在哪里，还有多远的路要走？
vaccines for genital infections: where are we and how far is there to go?
机构信息
Department of Pathology and Laboratory Medicine Medical Sciences, I, Room D440 University of California, Irvine, California, USA.
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
出版信息
Expert Rev Vaccines. 2021 Apr;20(4):421-435. doi: 10.1080/14760584.2021.1899817. Epub 2021 Apr 28.
Abstract
INTRODUCTION
is the most common sexually transmitted bacterial pathogen in the world. Antibiotic treatment does not prevent against reinfection and a vaccine is not yet available.
AREAS COVERED
We focus the review on the progress made of our understanding of the immunological responses required for a vaccine to elicit protection, and on the antigens, adjuvants, routes of immunization and delivery systems that have been tested in animal models. PubMed and Google Scholar were used to search publication on these topics for the last 5 years and recent Reviews were examined.
EXPERT OPINION
The first Phase 1 clinical trial of a vaccine to protect against genital infections was successfully completed. We expect that, in the next five years, additional vaccine clinical trials will be implemented.
摘要
简介
是世界上最常见的性传播细菌病原体。抗生素治疗并不能预防再次感染，而且目前还没有疫苗。
涵盖领域
我们重点回顾了在理解疫苗引发保护所需的免疫反应方面所取得的进展，以及在动物模型中测试过的抗原、佐剂、免疫途径和输送系统。在过去 5 年中，我们使用 PubMed 和 Google Scholar 搜索了这些主题的出版物，并查阅了最近的综述。
专家意见
预防生殖器感染的疫苗的首次 1 期临床试验已成功完成。我们预计，在未来五年内，将实施更多的疫苗临床试验。
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