在农村居民遗忘型轻度认知障碍中描绘全球和区域大脑结构：一项基于人群的研究。

Characterizing Global and Regional Brain Structures in Amnestic Mild Cognitive Impairment Among Rural Residents: A Population-Based Study.

机构信息

Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P. R. China.

Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.

出版信息

J Alzheimers Dis. 2021;80(4):1429-1438. doi: 10.3233/JAD-201372.

DOI:10.3233/JAD-201372

PMID:33682713

Abstract

BACKGROUND

Structural brain magnetic resonance imaging (MRI) scans may provide reliable neuroimaging markers for defining amnestic mild cognitive impairment (aMCI).

OBJECTIVE

We sought to characterize global and regional brain structures of aMCI among rural-dwelling older adults with limited education in China.

METHODS

This population-based study included 180 participants (aged≥65 years, 42 with aMCI and 138 normal controls) in the Shandong Yanggu Study of Aging and Dementia during 2014-2016. We defined aMCI following the Petersen's criteria. Global and regional brain volumes were automatically segmented on MRI scans and compared using a region-of-interest approach. Data were analyzed using general linear regression models.

RESULTS

Multi-adjusted β-coefficient (95% confidence interval) of brain volumes (cm3) associated with aMCI was -12.07 (-21.49, -2.64) for global grey matter (GM), -18.31 (-28.45, -8.17) for global white matter (WM), 28.17 (12.83, 44.07) for cerebrospinal fluid (CSF), and 2.20 (0.24, 4.16) for white matter hyperintensities (WMH). Furthermore, aMCI was significantly associated with lower GM volumes in bilateral superior temporal gyri, thalamus and right cuneus, and lower WM volumes in lateral areas extending from the frontal to the parietal, temporal, and occipital lobes, as well as right hippocampus (p < 0.05).

CONCLUSION

Brain structure of older adults with aMCI is characterized by reduced global GM and WM volumes, enlarged CSF volume, increased WMH burden, reduced GM volumes in bilateral superior temporal gyri, thalamus, and right cuneus, and widespread reductions of lateral WM volumes.

摘要

背景

结构性脑磁共振成像（MRI）扫描可为界定遗忘型轻度认知障碍（aMCI）提供可靠的神经影像学标志物。

目的

我们旨在对中国农村地区受教育程度有限的老年人群中，aMCI 的全脑和区域性脑结构进行特征描述。

方法

本基于人群的研究纳入了 2014-2016 年在山东阳谷进行的老龄化与痴呆研究中的 180 名参与者（年龄≥65 岁，42 名患有 aMCI，138 名正常对照）。我们根据 Petersen 标准定义 aMCI。在 MRI 扫描上自动对全脑和区域性脑容量进行分割，并使用感兴趣区方法进行比较。使用一般线性回归模型进行数据分析。

结果

校正后，与 aMCI 相关的脑容量（cm3）多变量β系数（95%置信区间）为全脑灰质（GM）-12.07（-21.49，-2.64），全脑白质（WM）-18.31（-28.45，-8.17），脑脊液（CSF）28.17（12.83，44.07），脑白质高信号（WMH）2.20（0.24，4.16）。此外，aMCI 与双侧颞上回、丘脑和右侧楔前叶 GM 容积降低，额、顶、颞、枕叶外侧区 WM 容积降低以及右侧海马 WM 容积降低显著相关（p < 0.05）。