Department of Medical Physics, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkiye.
Department of Neuroscience, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkiye.
Turk J Med Sci. 2024 Mar 11;54(3):588-597. doi: 10.55730/1300-0144.5826. eCollection 2024.
BACKGROUND/AIM: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia, and thus, it is of interest to enlighten specific brain atrophy patterns in aMCI patients. We aim to define the longitudinal atrophy pattern in subcortical structures and its effect on cognition in patients with aMCI.
Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB's integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and amygdala). Correlations between volumes and cognitive performance were assessed.
Compared with healthy controls, aMCI demonstrated subcortical atrophies in the hippocampus (p = 0.001), nucleus accumbens (p = 0.003), and thalamus (p = 0.003) at baseline. Significant associations were found for the baseline volumes of the thalamus, nucleus accumbens, and hippocampus with memory, the thalamus with visuospatial skills.
aMCI demonstrated subcortical atrophies associated with cognitive deficits. The thalamus, nucleus accumbens, and hippocampus may provide additional diagnostic information for aMCI.
背景/目的：遗忘型轻度认知障碍（aMCI）是痴呆的危险因素，因此，了解 aMCI 患者的特定脑萎缩模式具有重要意义。我们旨在定义 aMCI 患者亚皮质结构的纵向萎缩模式及其对认知的影响。
研究了 20 名 aMCI 患者和 20 名在基线和纵向结构磁共振成像扫描和神经心理学评估方面与年龄匹配的健康对照者。使用算法 FIRST（FMRIB 的综合注册和分割工具）获得亚皮质结构（丘脑、壳核、尾状核、伏隔核、苍白球、海马和杏仁核）的体积。评估了体积与认知表现之间的相关性。
与健康对照组相比，aMCI 在基线时显示出海马体（p=0.001）、伏隔核（p=0.003）和丘脑（p=0.003）的亚皮质萎缩。在记忆方面，丘脑、伏隔核和海马体的基线体积与记忆相关，而丘脑与视觉空间技能相关。
aMCI 表现出与认知缺陷相关的亚皮质萎缩。丘脑、伏隔核和海马体可能为 aMCI 提供额外的诊断信息。
