Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China.
Alzheimers Dement. 2024 Oct;20(10):6669-6681. doi: 10.1002/alz.13924. Epub 2024 Aug 22.
We examined the associations of polygenic risk score (PRS) with Alzheimer's disease (AD) and plasma biomarkers in the Chinese population.
This population-based study used baseline data from MIND-China (2018; n = 4873) and follow-up data from dementia-free individuals (2014-2018; n = 2117). We measured AD-related plasma biomarkers in a subsample (n = 1256). Data were analyzed using logistic and Cox regression models.
We developed PRS with (PRS) and without (PRS ) apolipoprotein E (APOE) gene. In the longitudinal analysis, PRS was associated with a multivariable-adjusted hazards ratio of 1.91 (95% CI = 1.13-3.23) for AD. PRS in combination with demographics yielded discriminative (area under the curve [AUC]) and predictive(C-statistic) accuracy of 0.80 (95% confidence interval [CI] = 0.77-0.84) and 0.80 (0.77-0.82), respectively. PRS showed an association with AD risk similar to PRS. PRS, but not PRS , was associated with reduced plasma Aβ42/Aβ40 ratio and increased Neurofilament light chain (NfL) (p < 0.05).
The PRS with and without APOE gene, in combination with demographics, shows good discriminative and predictive ability for AD. The AD-related pathologies underlie AD risk associated with PRS.
The PRS and PRS were associated with AD risk in the Chinese population. The PRS and PRS , in combination with demographics, showed good discriminative and predictive ability for AD. The AD-related pathologies underlie the AD risk associated with PRS but not PRS .
我们研究了多基因风险评分（PRS）与中国人群阿尔茨海默病（AD）和血浆生物标志物的相关性。
本研究基于人群，使用 MIND-China 项目（2018 年；n=4873）的基线数据和无痴呆个体（2014-2018 年；n=2117）的随访数据。我们在亚组（n=1256）中测量了与 AD 相关的血浆生物标志物。数据分析采用逻辑回归和 Cox 回归模型。
我们开发了包含（PRS）和不包含（PRS）载脂蛋白 E（APOE）基因的 PRS。在纵向分析中，PRS 与多变量校正后的 AD 风险比为 1.91（95%可信区间[CI]：1.13-3.23）。PRS 与人口统计学因素相结合，其区分度（曲线下面积[AUC]）和预测准确性（C 统计量）分别为 0.80（95%CI：0.77-0.84）和 0.80（0.77-0.82）。PRS 与 AD 风险的相关性与 PRS 相似。PRS 与血浆 Aβ42/Aβ40 比值降低和神经丝轻链（NfL）升高有关（p<0.05），而 PRS 则无此相关性。
包含和不包含 APOE 基因的 PRS 与人口统计学因素相结合，对 AD 具有良好的区分度和预测能力。PRS 相关的 AD 病理基础解释了与 PRS 相关的 AD 风险。
PRS 和 PRS 与中国人群的 AD 风险相关。PRS 和 PRS 与人口统计学因素相结合，对 AD 具有良好的区分度和预测能力。PRS 相关的 AD 病理基础解释了与 PRS 相关的 AD 风险，但与 PRS 无关。
