School of Electrical Engineering, Tel Aviv University, Tel Aviv, Israel.
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
J Parkinsons Dis. 2021;11(s1):S71-S76. doi: 10.3233/JPD-202412.
Sleep disturbances are prevalent in neurodegenerative diseases in general, and in Parkinson's disease (PD) in particular. Recent evidence points to the clinical value of sleep in disease progression and improving quality of life. Therefore, monitoring sleep quality in an ongoing manner at the convenience of one's home has the potential to improve clinical research and to contribute to significantly better personalized treatment. Further, precise mapping of sleep patterns of each patient can contribute to a better understanding of the disease, its progression and the appropriate medical treatment. Here we review selective, state-of-the-art, home-based devices for assessing sleep and sleep related disorders. We highlight the large potential as well as the main challenges. In particular, we discuss medical validity, standardization and regulatory concerns that currently impede widespread clinical adoption of existing devices. Finally, we propose a roadmap with the technological and scientific steps that are required to impact PD research and treatment.
睡眠障碍在一般神经退行性疾病中很常见，在帕金森病（PD）中尤其如此。最近的证据表明，睡眠在疾病进展和提高生活质量方面具有临床价值。因此，在家中方便的情况下持续监测睡眠质量有可能改善临床研究并有助于提供显著更好的个性化治疗。此外，精确绘制每个患者的睡眠模式有助于更好地了解疾病、其进展和适当的医疗。在这里，我们回顾了用于评估睡眠和睡眠相关障碍的精选、最先进的家用设备。我们强调了巨大的潜力以及主要挑战。特别是，我们讨论了目前阻碍现有设备广泛临床应用的医学有效性、标准化和监管问题。最后，我们提出了一个路线图，其中包含了影响 PD 研究和治疗所需的技术和科学步骤。
