评价新型除虫脲对（坠落）（双翅目：蝇科）的毒性效应。
Evaluation of the Toxic Effects of Novaluron on (Fallen) (Diptera: Muscidae).
出版信息
Pak J Biol Sci. 2021 Jan;24(1):42-52. doi: 10.3923/pjbs.2021.42.52.
BACKGROUND AND OBJECTIVE
The worldwide fly species, Muscina stabulans (Diptera: Muscidae) is known as 'false stable fly'. It has veterinary, forensic and medical importance. The present study aimed to examine the toxicity of novaluron (chitin synthesis inhibitor) via its effect on the growth and reproductive potential of M. stabulans.
MATERIALS AND METHODS
The early last (3rd) instar larvae and prepupae have been treated with novaluron using five doses: 5.0, 1.0, 0.5, 0.1 and 0.01 μg/larva. Student's t-test analysis has been used for data processing as well as refined by Bessel correction for significant differences among means.
RESULTS
Current study revealed that, after the treatment different mortalities of larva, pupa and adult have been estimated. LD50 values of novaluron were 0.018 and 0.057 μg/insect, respectively. Furthermore, the larval period was insignificantly shortened while the pupal duration has been significantly extended and the developmental rate has been slightly enhanced. On the other hand, the adult longevity of females was considerably reduced and the adult emergence was considerably blocked, regardless the dose. However, only after the treatment, some deformed pupae were observed and some adult deformities were observed. Both fecundity and fertility were drastically reduced and sterilizing activity on novaluron increased in a dose-dependent course, regardless the time of treatment.
CONCLUSION
Novaluron can be used as an effective IGR in the integrated control program for this medically and veterinary serious fly.
背景与目的
世界性的蝇种 Muscina stabulans（双翅目：蝇科）被称为“假厩蝇”。它具有兽医、法医和医学重要性。本研究旨在通过其对 M. stabulans 生长和生殖潜力的影响来检验 novaluron（几丁质合成抑制剂）的毒性。
材料与方法
使用 novaluron 处理早期的 3 龄幼虫和预蛹，使用 5 个剂量：5.0、1.0、0.5、0.1 和 0.01 μg/幼虫。学生 t 检验分析用于数据处理，并通过贝塞尔校正进行了显著差异的细化。
结果
本研究表明，处理后幼虫、蛹和成虫的死亡率不同。novaluron 的 LD50 值分别为 0.018 和 0.057 μg/昆虫。此外，幼虫期明显缩短，而蛹期明显延长，发育速度略有提高。另一方面，雌成虫的寿命显著降低，成虫的出现被严重阻断，无论剂量如何。然而，只有在处理后，才观察到一些畸形蛹和一些成虫畸形。无论处理时间如何，繁殖力和生育力都急剧下降，novaluron 的绝育活性呈剂量依赖性增加。
结论
novaluron 可作为一种有效的 IGR 用于该具有医学和兽医重要性的严重蝇类的综合控制计划。
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