International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, NO. 910, Heng-Shan Road, Xu-Hui Qu, Shanghai, 200030, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, China.
Reprod Sci. 2021 Aug;28(8):2378-2386. doi: 10.1007/s43032-021-00513-6. Epub 2021 Mar 8.
Adenomyosis is associated with dysmenorrhea, infertility, and lesional fibrosis. The pathogenesis of adenomyosis is still unclear. Plasminogen activator inhibitor 1 (PAI-1) plays important roles in pathological activities like tumor metastasis and endometriosis. Our objective was to investigate the expression and localization of PAI-1 in eutopic and ectopic endometrium with adenomyosis and in endometrium without adenomyosis. We also sought to determine the relationship between PAI-1 immunoreactivity and the severity of dysmenorrhea and the extent of lesional fibrosis in adenomyosis. PAI-1 expression was significantly higher in the ectopic endometrium of patients with adenomyosis than in both the eutopic endometrium of patients with adenomyosis and the endometrium of controls. Ectopic PAI-1 expression correlated positively with dysmenorrhea visual analog scale (VAS) scores and the extent of lesional fibrosis in adenomyosis. High PAI-1 expression increased the likelihood of moderate to severe dysmenorrhea in adenomyosis. These results suggest that PAI-1 is involved in the adenomyosis-associated dysmenorrhea and lesional fibrosis, which provide a potential target in treating symptomatic adenomyosis.
子宫腺肌病与痛经、不孕和病灶纤维化有关。其发病机制尚不清楚。纤溶酶原激活物抑制剂 1（PAI-1）在肿瘤转移和子宫内膜异位症等病理活动中发挥重要作用。我们的目的是研究 PAI-1 在伴有和不伴有子宫腺肌病的异位和在位子宫内膜中的表达和定位，并探讨 PAI-1 免疫反应性与痛经严重程度和子宫腺肌病病灶纤维化程度之间的关系。子宫腺肌病患者的异位子宫内膜中 PAI-1 的表达明显高于子宫腺肌病患者的在位子宫内膜和对照组的子宫内膜。异位 PAI-1 的表达与痛经视觉模拟评分（VAS）呈正相关，也与子宫腺肌病病灶纤维化的程度相关。高 PAI-1 表达增加了子宫腺肌病中度至重度痛经的可能性。这些结果表明，PAI-1 参与了与子宫腺肌病相关的痛经和病灶纤维化，为治疗有症状的子宫腺肌病提供了一个潜在的靶点。
