Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
BJOG. 2021 Sep;128(10):1598-1609. doi: 10.1111/1471-0528.16692. Epub 2021 Apr 6.
To describe the prevalence and incidence of endometriosis and to estimate the risk of cardiovascular outcomes in women with endometriosis.
Population-based cohort study using The Health Improvement Network database.
UK primary care.
Women aged 16-50 years were followed from 1995 to 2018.
Adjusted hazard ratios (aHR) for cardiovascular outcomes comparing women with endometriosis with those without endometriosis were estimated using multivariable Cox regression models. Prevalence and incidence of endometriosis were estimated using annual (1998-2017) sequential cross-sectional and cohort studies, respectively.
The primary outcome was composite cardiovascular disease (CVD) including, ischaemic heart disease (IHD), heart failure (HF) and cerebrovascular disease. Secondary outcomes were arrhythmia, hypertension and all-cause mortality.
In all, 56 090 women with endometriosis and 223 669 matched controls without endometriosis were included in the analysis of cardiovascular risk. Compared with women without endometriosis, the aHR for cardiovascular outcomes among women with endometriosis were: composite CVD 1.24 (95% CI 1.13-1.37); IHD 1.40 (95% CI 1.22-1.61); cerebrovascular disease 1.19 (95% CI 1.04-1.36); HF 0.76 (95% CI 0.54-1.07); arrhythmia 1.26 (95% CI 1.11-1.43); hypertension 1.12 (95% CI 1.07-1.17) and all-cause mortality 0.66 (95% CI 0.59-0.74). The incidence of endometriosis was 12.3 per 10 000 person-years in 1998 and 11.5 per 10 000 person-years in 2017. The prevalence of endometriosis increased from 119.7 per 10 000 population in 1998 to 201.3 per 10 000 population in 2017.
Endometriosis is associated with an increased risk of cardiovascular outcomes. Young women with endometriosis are a potential target for CVD risk assessment and prevention.
Endometriosis is associated with increased risk of cardiovascular outcomes: a UK retrospective matched cohort study.
描述子宫内膜异位症的患病率和发病率，并估计子宫内膜异位症患者发生心血管结局的风险。
利用 The Health Improvement Network 数据库进行的基于人群的队列研究。
英国初级保健。
1995 年至 2018 年期间，年龄在 16-50 岁的女性参与了研究。
使用多变量 Cox 回归模型估计比较患有子宫内膜异位症的女性与没有子宫内膜异位症的女性发生心血管结局的调整后风险比 (aHR)。通过每年（1998-2017 年）的连续横断面研究和队列研究，分别估计子宫内膜异位症的患病率和发病率。
主要结局是包括缺血性心脏病 (IHD)、心力衰竭 (HF) 和脑血管疾病在内的复合心血管疾病 (CVD)。次要结局指标包括心律失常、高血压和全因死亡率。
在总共纳入的 56090 例患有子宫内膜异位症的女性和 223669 例匹配的无子宫内膜异位症对照者中，分析了心血管风险。与无子宫内膜异位症的女性相比，患有子宫内膜异位症的女性发生心血管结局的 aHR 为：复合 CVD 1.24（95%CI 1.13-1.37）；IHD 1.40（95%CI 1.22-1.61）；脑血管疾病 1.19（95%CI 1.04-1.36）；HF 0.76（95%CI 0.54-1.07）；心律失常 1.26（95%CI 1.11-1.43）；高血压 1.12（95%CI 1.07-1.17）和全因死亡率 0.66（95%CI 0.59-0.74）。1998 年子宫内膜异位症的发病率为每 10000 人年 12.3 例，2017 年为每 10000 人年 11.5 例。1998 年子宫内膜异位症的患病率为每 10000 人 119.7 例，到 2017 年增加到每 10000 人 201.3 例。
子宫内膜异位症与心血管结局风险增加相关。患有子宫内膜异位症的年轻女性是心血管疾病风险评估和预防的潜在目标人群。
子宫内膜异位症与心血管结局风险增加相关：一项英国回顾性匹配队列研究。
