Division of Laboratory Medicine, Marshfield Clinic Health System, Marshfield, WI, USA.
Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Ear Nose Throat J. 2023 Apr;102(4):NP157-NP160. doi: 10.1177/0145561321991342. Epub 2021 Mar 8.
Otolaryngologic manifestations of infection with species are extremely rare and restricted geographically to recognized endemic regions. Here, we describe a case of laryngeal blastomycosis that presented as slowly progressive dysphonia. While a preliminary diagnosis was made using routine histopathology, a species identification of was made using polymerase chain reaction amplification and rapid genotyping without the need for fungal culture. All symptoms resolved following 1 month of antifungal therapy. Rapid molecular differentiation of from provides important insights into pathogenesis given recent recognition of differences in clinical spectra.
感染 物种引起的耳鼻喉表现极为罕见，且在地理上仅限于公认的地方性流行区域。在此，我们描述了一例以进行性声音嘶哑为表现的喉放线菌病。虽然常规组织病理学做出了初步诊断，但通过聚合酶链反应扩增和快速基因分型而无需真菌培养来鉴定 物种为 。在接受 1 个月的抗真菌治疗后，所有症状均得到缓解。鉴于最近认识到临床谱的差异，从 中快速区分 提供了对发病机制的重要见解。
