Bradsher R W
Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock.
Infect Dis Clin North Am. 1988 Dec;2(4):877-98.
Blastomycosis is a rare systemic fungal infection caused by Blastomyces dermatitidis, which is often difficult to diagnose because of its spectrum of manifestations, varying severity, and unusual occurrence in most geographic areas. Because routine serologic methods and skin tests are not reliable for this pathogen, diagnosis is made by visualization of the organism in tissue, sputum, or exudate, or by culture. Once blastomycosis is diagnosed, therapeutic options include treatment with amphotericin B or ketoconazole, or simple observation if spontaneous resolution is anticipated. The purpose of this discussion is to review the features of blastomycosis that relate to the clinical practice of medicine.
芽生菌病是一种由皮炎芽生菌引起的罕见的全身性真菌感染，由于其表现形式多样、严重程度各异且在大多数地理区域发病率不高，常常难以诊断。因为针对这种病原体，常规血清学方法和皮肤试验并不可靠，所以诊断需通过在组织、痰液或渗出物中发现该病原体，或通过培养来进行。一旦诊断出芽生菌病，治疗选择包括用两性霉素B或酮康唑进行治疗，或者如果预计会自然痊愈则进行单纯观察。本次讨论的目的是回顾与医学临床实践相关的芽生菌病的特征。
