Ophthalmology Department, Konyagoz Eye Hospital, Konya, Turkey.
J Ocul Pharmacol Ther. 2021 May;37(4):230-235. doi: 10.1089/jop.2020.0144. Epub 2021 Mar 8.
In this study, we wanted to retrospectively evaluate the effect of the use of topical brimonidine on intraoperative bleeding and surgical hemostasis before strabismus surgery. Brimonidine tartrate 0.15% (Brimogut, Bilim Ilac, Turkey) eye drops were applied 6 and 3 min before surgery to 44 eyes of 22 patients in group 1 for vasoconstriction. Drops were not applied to 46 eyes of 23 patients in group 2. Preoperative and postoperative photographs and video images were taken. Black-and-white images were used to define the surface areas of the blood vessels. The surface area was calculated by counting the black pixels with ImageJ software. In group 1, redness of eye was observed, on average, at preoperative 339.25 ± 11.52 pixels and intraoperative 247.93 ± 10.63 pixels ( < 0.001). But there was no change in group 2 (preoperative 338.87 ± 8.45 pixels to intraoperative 339.71 ± 9.52 pixels, > 0.05). The incidence of intraoperative bleeding evaluated by the number of eyes on which cautery was used shows that it was significantly less in group 1 than in group 2 ( < 0.001). The use of topical brimonidine before strabismus surgery facilitates clear monitoring of anatomical structures during surgery by effectively controlling hemorrhage. In the postoperative period, it significantly reduces subconjunctival hemorrhage.
在这项研究中，我们回顾性评估了斜视术前使用局部盐酸肾上腺素滴眼剂对术中出血和手术止血的影响。 1 组 22 例患者的 44 只眼在术前 6 分钟和 3 分钟时滴用 0.15%酒石酸溴莫尼定滴眼液（Brimogut，Bilim Ilac，土耳其）进行血管收缩，而 2 组 23 例患者的 46 只眼未滴用。记录术前和术后的照片和视频图像。黑白图像用于定义血管的表面积。通过 ImageJ 软件计算黑色像素的数量来计算表面积。在 1 组中，观察到眼的平均术前发红为 339.25±11.52 像素，术中为 247.93±10.63 像素（ < 0.001）。而 2 组中没有变化（术前 338.87±8.45 像素到术中 339.71±9.52 像素， > 0.05）。通过使用电烙术的眼睛数量评估术中出血发生率，结果表明 1 组明显少于 2 组（ < 0.001）。斜视术前使用局部肾上腺素滴眼剂可有效控制出血，便于术中清晰监测解剖结构。在术后期间，它显著减少了球结膜下出血。
