Hill T L
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Proc Natl Acad Sci U S A. 1988 May;85(10):3271-5. doi: 10.1073/pnas.85.10.3271.
Three problems are considered. The first is the relation between ensemble-averaged state probabilities in a random walk with absorption and time-averaged state probabilities in the corresponding closed diagram. The second problem is concerned with random walks on diagrams with cycles in which the cycle completion rates and probabilities may depend on the "remainder" after the previously completed cycle. The final topic is a study of cycle completions prior to absorption for diagrams that involve both cycles and absorption (e.g., a cycling enzyme that binds a dead-end inhibitor or poison in one of its states).
考虑了三个问题。第一个问题是具有吸收的随机游走中的系综平均状态概率与相应封闭图中的时间平均状态概率之间的关系。第二个问题涉及具有循环的图上的随机游走,其中循环完成率和概率可能取决于先前完成的循环之后的“余数”。最后一个主题是研究涉及循环和吸收的图(例如,一种在其一种状态下结合终产物抑制剂或毒物的循环酶)在吸收之前的循环完成情况。