Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad, 38000, Pakistan.
Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad, 38000, Pakistan; International Society of Engineering Science and Technology, Coventry, CV1 5EH, United Kingdom.
Leuk Res. 2021 May;104:106554. doi: 10.1016/j.leukres.2021.106554. Epub 2021 Mar 2.
Lymphoma is a heterogeneous group of malignancies, which comprises 4.2 % of all new cancer cases and 3.3 % of all cancer deaths in 2019, globally. The dysregulation of immune system, certain bacterial or viral infections, autoimmune diseases, and immune suppression are associated with a high risk of lymphoma. Although several conventional strategies have improved during the past few decades, but their detrimental impacts remain an obstacle to be resolved. However, natural compounds are considered a good option in the treatment of lymphomas because of their easy accessibility, specific mode of action, high biodegradability, and cost-effectiveness. Vegetables, fruits, and beverages are the primary sources of natural active compounds. The present review investigated the activities of different natural medicinal compounds including curcumin, MK615, resveratrol, bromelain, EGCG, and Annonaceous acetogenins to treat lymphomas. Moreover, in vitro and in vivo studies, classification, risk factors, and diagnosis of lymphoma are also discussed in the present review. The accumulated data proposed that natural compounds regulate the signaling pathways at the level of cell proliferation, apoptosis, and cell cycle to exhibit anti-lymphoma activities both in-vivo and in-vitro studies and suggested that these active compounds could be a good therapeutic option in the treatment of different types of lymphomas.
淋巴瘤是一组异质性恶性肿瘤，2019 年，其在全球所有新癌症病例中占 4.2%，在所有癌症死亡病例中占 3.3%。免疫系统失调、某些细菌或病毒感染、自身免疫性疾病和免疫抑制与淋巴瘤的高风险相关。尽管在过去几十年中，几种常规策略有所改善，但它们的有害影响仍然是一个亟待解决的障碍。然而，由于天然化合物易于获取、作用模式特异、高生物降解性和成本效益高，因此被认为是治疗淋巴瘤的一种较好选择。蔬菜、水果和饮料是天然活性化合物的主要来源。本综述研究了不同天然药用化合物的活性，包括姜黄素、MK615、白藜芦醇、菠萝蛋白酶、EGCG 和番荔枝烷酮，以治疗淋巴瘤。此外，本综述还讨论了淋巴瘤的体外和体内研究、分类、危险因素和诊断。积累的数据表明，天然化合物通过调节细胞增殖、凋亡和细胞周期水平的信号通路，在体内和体外研究中均表现出抗淋巴瘤活性，提示这些活性化合物可能是治疗不同类型淋巴瘤的一种较好的治疗选择。
