Facultad de Medicina, Hospital Aranda de la Parra, Universidad de Guanajuato, 37000 León, Guanajuato. Mexico.
Servicio de Micología, Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, Ciudad de México, Mexico.
J Mycol Med. 2021 Jun;31(2):101114. doi: 10.1016/j.mycmed.2021.101114. Epub 2021 Jan 19.
Chromoblastomycosis is a chronic subcutaneous fungal infection caused by melanized fungi. It is usually an occupational mycosis affecting people in rural areas in tropical and subtropical regions. We present two cases of chromoblastomycosis in Mexican farmers, characterized by skin verrucous plaques. Direct examination with KOH 10% showed the presence of muriform cells. The fungal isolation was carried out in Sabouraud dextrose agar and molecular identification was achieved by 18S-ITS1-5.8S-ITS2-28S rRNA gene amplification and sequencing. Fonsecaeamonophora was identified in both cases. A therapy with itraconazole and terbinafine was used with a partial favorable response. However, patients did not return for medical examination after 4 months. The current status of the patients is unknown. We reported the first two cases of chromoblastomycosis caused by F. monophora in Mexico.
着色芽生菌病是一种由黑霉菌引起的慢性皮下真菌感染。它通常是一种职业性真菌病，影响热带和亚热带地区农村地区的人群。我们报告了两例墨西哥农民的着色芽生菌病病例，其特征为皮肤疣状斑块。KOH 10%直接检查显示存在多形细胞。在萨布罗琼脂上进行真菌分离，并通过 18S-ITS1-5.8S-ITS2-28S rRNA 基因扩增和测序进行分子鉴定。在两种情况下均鉴定为单端孢属。使用伊曲康唑和特比萘芬进行治疗，部分反应良好。然而，患者在 4 个月后没有回来接受体检。目前患者的情况尚不清楚。我们报告了墨西哥首例由 F. monophora 引起的着色芽生菌病的两例病例。
