Ankara Training and Research Hospital, Clinic of Medical Microbiology, Ankara, Turkey
Hacettepe University Faculty of Medicine, Department of Infectious Diseases, Ankara, Turkey
Turkiye Parazitol Derg. 2021 Mar 2;45(1):39-44. doi: 10.4274/tpd.galenos.2020.6819.
Immunocompromised patients are at a greater risk of developing intestinal parasite infections. In this study, we examined the presence of and other intestinal protozoa in stool samples of immunosuppressed patients.
A total of 100 stool samples were obtained from patients receiving chemotherapy because of solid organ tumour with haematological malignancies and those receiving immunosuppressive treatment because of rheumatic diseases, organ transplant patients and patients receiving treatment for HIV-related infections. Stool samples were examined by using the native-lugol method in which the stool concentration, modified Kinyoun acid-fast and trichrome staining methods and parasite presence were analysed. The stool samples were also examined for the presence of and using an indirect fluorescent antibody method.
Intestinal parasites were detected in 12% of all patients. The distribution of intestinal parasites in patients were 7% spp., 2% spp. + , 1% spp. + , 1% spp. + and 1% spp. were detected in 4% of all patients by the IFAT method and in 8% of all patients by calcoflour staining method.
In our study, the most prevalent parasite detected in the immunosuppressed patients was spp. The pathogenesis of spp. remains to be controversial, and their role in immunocompromised patients continues to remain unknown. Although these rates detected in our study are similar to the prevalence in the normal population, it is important to study these microorganisms in immunocompromised patients in terms of the associated decreasing morbidity and mortality rates.
免疫功能低下的患者发生肠道寄生虫感染的风险更高。本研究旨在检测免疫抑制患者粪便样本中是否存在 和其他肠道原虫。
共采集了 100 例粪便样本，这些患者因实体器官肿瘤伴血液病而接受化疗、因风湿性疾病而接受免疫抑制治疗、器官移植患者以及因 HIV 相关感染而接受治疗。采用自然卢戈氏碘液法检查粪便样本，分析粪便浓缩物、改良金尼翁抗酸染色和三色染色法以及寄生虫存在情况。还采用间接荧光抗体法检测 和 。
所有患者中有 12%检测到肠道寄生虫。寄生虫在患者中的分布情况为：7% 属、2% 属+ 、1% 属+ 、1% 属+ 、1% 属，通过间接荧光抗体法在所有患者中检测到 4%，通过Calcofluor 染色法在所有患者中检测到 8%。
在本研究中，免疫抑制患者中最常见的寄生虫是 属。 的发病机制仍存在争议，其在免疫抑制患者中的作用尚不清楚。尽管我们研究中检测到的这些比率与普通人群的流行率相似，但研究免疫抑制患者中这些微生物的作用对于降低发病率和死亡率非常重要。
