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新冠疫情期间抗生素的使用。

Use of antibiotics during the COVID-19 pandemic.

出版信息

Tidsskr Nor Laegeforen. 2021 Feb 12;141(4). doi: 10.4045/tidsskr.20.1003. Print 2021 Mar 9.

Abstract

BACKGROUND

Interest has been shown in the use of antibiotics during the COVID-19 pandemic. In this article we present the consumption of systemic antibiotics in Norway during the period of the pandemic.

MATERIAL AND METHOD

Total sales of systemic antibiotics in defined daily doses (DDD) were retrieved from the wholesaler-based medicinal product statistics for 2019 and 2020, and sales of antibiotics for use outside of healthcare institutions were retrieved from the Norwegian prescription database. Information was retrieved on the proportion of users (prevalence), doses (measured in DDD) and prescriptions.

RESULTS

Total sales of systemic antibiotics increased in March 2020, but sales to persons outside of healthcare institutions did not. Compared to previous years, both total consumption and use of antibiotics outside of institutions fell steeply in the months that followed. The reduction was greatest for antibiotics against respiratory infections and in the youngest age groups.

INTERPRETATION

The significant reduction in the use of systemic antibiotics during the COVID-19 pandemic is attributed to infection control measures and reduced contact with the health service. In 2016, the Norwegian government set a goal for a 30 % reduction in antibiotic use by the end of 2020. The pandemic has contributed to the achievement of that goal.

摘要

背景

在 COVID-19 大流行期间,人们对使用抗生素产生了兴趣。本文介绍了大流行期间挪威系统用抗生素的使用情况。

材料和方法

从批发商药品统计数据中检索了 2019 年和 2020 年的系统用抗生素定义日剂量(DDD)的总销售额,并从挪威处方数据库中检索了医疗机构外使用的抗生素销售额。检索了使用者的比例(患病率)、剂量(以 DDD 表示)和处方信息。

结果

2020 年 3 月,系统用抗生素的总销售额增加,但医疗机构外的销售额并未增加。与前几年相比,随后的几个月中,总消耗量和医疗机构外抗生素的使用量急剧下降。降幅最大的是针对呼吸道感染的抗生素和年龄最小的人群。

解释

COVID-19 大流行期间系统用抗生素的使用显著减少归因于感染控制措施和与卫生服务的接触减少。2016 年,挪威政府设定了到 2020 年底抗生素使用量减少 30%的目标。大流行有助于实现这一目标。

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