Simoni Jane M, Beima-Sofie Kristin, Wanje George, Mohamed Zahra H, Tapia Kenneth, McClelland R Scott, Ho Rodney J Y, Collier Ann C, Graham Susan M
Department of Psychology, 7284University of Washington, Seattle Washington, USA.
Department of Global Health, 7284University of Washington, Seattle Washington, USA.
J Int Assoc Provid AIDS Care. 2021 Jan-Dec;20:23259582211000517. doi: 10.1177/23259582211000517.
Long-acting injectable (LAI) antiretroviral therapy (ART) may offer persons living with HIV (PLWH) an attractive alternative to pill-based treatment options, yet acceptability data remain scant, especially in sub-Saharan Africa.
We conducted 6 focus group discussions with PLWH, including key stake holder groups, and analyzed data with content analysis.
Initial reactions to the idea of LAI-ART were often positive. The primary advantages voiced were potential to facilitate improved adherence and alleviate the burden of daily pill-taking while avoiding inadvertent disclosure and HIV stigma. Potential side effects were a particular concern of the women. Most participants preferred clinic-based administration over self-injections at home due to concerns about safety, privacy, and potential need for refrigeration.
LAI-ART may be acceptable in Kenya, provided injections are infrequent and delivered in a clinic setting. However, HIV stigma, fear of potential side effects, and limited clinical capacity would need to be addressed.
长效注射用抗逆转录病毒疗法（ART）可能为艾滋病毒感染者（PLWH）提供一种有吸引力的替代口服药物治疗方案的选择，但关于其可接受性的数据仍然很少，尤其是在撒哈拉以南非洲地区。
我们与包括关键利益相关者群体在内的艾滋病毒感染者进行了6次焦点小组讨论，并采用内容分析法对数据进行了分析。
对长效注射用抗逆转录病毒疗法这一想法的最初反应通常是积极的。提到的主要优点包括有可能促进更好的依从性，减轻每日服药负担，同时避免无意中暴露病情和感染艾滋病毒带来的耻辱感。潜在的副作用是女性特别关注的问题。由于担心安全、隐私以及可能需要冷藏，大多数参与者更喜欢在诊所进行注射，而不是在家自行注射。
在肯尼亚，只要注射频率不高且在诊所环境中进行，长效注射用抗逆转录病毒疗法可能是可以接受的。然而，需要解决艾滋病毒带来的耻辱感、对潜在副作用的担忧以及临床能力有限等问题。
