AbbVie Inc, North Chicago, IL, USA.
HealthMetrics Outcomes Research, Bonita Springs, FL, USA.
J Med Econ. 2021 Jan-Dec;24(1):440-446. doi: 10.1080/13696998.2021.1900202.
To examine direct and indirect economic burden associated with hypothyroidism in the United States.
Medical costs attributable to hypothyroidism were estimated for patients with hypothyroidism. Non-hypothyroid (euthyroid) controls were matched to patients with hypothyroidism based upon patient characteristics and availability of productivity data. Multivariable analyses examined resource utilization, annual medical costs, comorbidities, and productivity costs.
Estimates of hypothyroidism-related total medical costs ranged from $460 to $2,555 per patient per year. Compared to euthyroid controls, patients with hypothyroidism had significantly higher all-cause medical costs and medical resource utilization. For the subset of patients with available productivity data, hypothyroidism was associated with significantly higher absenteeism and long- and short-term disability costs but significantly lower worker's compensation costs.
Hypothyroidism is associated with significant direct and indirect economic burden among employed, commercially insured patients in the US. Despite the availability of relatively inexpensive generic therapies for hypothyroidism, this study found significant direct and indirect costs associated with the condition. The large number of patients diagnosed with hypothyroidism combined with increased costs associated with hypothyroidism result in a significant burden for patients, payers, and employers.
在美国，研究与甲状腺功能减退症相关的直接和间接经济负担。
对甲状腺功能减退症患者的甲状腺功能减退症相关医疗费用进行了估计。根据患者特征和生产力数据的可用性，将非甲状腺功能减退症（甲状腺功能正常）对照组与甲状腺功能减退症患者相匹配。多变量分析考察了资源利用、年度医疗费用、合并症和生产力成本。
估计甲状腺功能减退症相关的总医疗费用为每位患者每年 460 至 2555 美元。与甲状腺功能正常对照组相比，甲状腺功能减退症患者的全因医疗费用和医疗资源利用明显更高。对于具有可用生产力数据的患者亚组，甲状腺功能减退症与旷工和长期及短期残疾成本显著增加相关，但与工人赔偿成本显著降低相关。
在美国，甲状腺功能减退症与就业、商业保险患者的直接和间接经济负担显著相关。尽管甲状腺功能减退症有相对便宜的通用治疗方法，但本研究发现与该疾病相关的直接和间接费用显著。大量被诊断为甲状腺功能减退症的患者加上与甲状腺功能减退症相关的成本增加，给患者、支付者和雇主带来了巨大的负担。
