新加坡危重症新冠病毒肺炎患者静脉血栓形成发生率低，但动脉血栓形成并发症发生率高。
Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore.
作者信息
Tan Chuen Wen, Fan Bingwen Eugene, Teo Winnie Z Y, Tung Moon Ley, Shafi Humaira, Christopher Dheepa, Zheng Shuwei, Peh Wee Ming, Chan Stephrene Seok Wei, Chong Vanessa Cui Lian, Gallardo Christian Aledia, Chang Cheng Chieh Ray, Ling Li Min, Tan Jing Yuan, Lee Ken Cheah Hooi, Phua Ghee Chee, Cherng Benjamin Pei Zhi, Low Jenny Guek Hong, Ho Vui Kian, Prasad Vishnu, Wong Lester Jung Long, Lim Cheryl Xiu Qi, Chee Yen Lin, Ong Kiat Hoe, Lee Lai Heng, Ng Heng Joo, Yap Eng Soo
机构信息
Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore.
出版信息
Thromb J. 2021 Mar 8;19(1):14. doi: 10.1186/s12959-021-00268-9.
Abstract
BACKGROUND
Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients.
METHOD AND RESULTS
This is a national multicenter retrospective observational study involving all consecutive adult COVID-19 patients who required intensive care units (ICU) admission between 23 January 2020 and 30 April 2020 in Singapore. One hundred eleven patients were included and the venous and arterial thrombotic rates in ICU were 1.8% (n = 2) and 9.9% (n = 11), respectively. Major bleeding rate was 14.8% (n = 16).
CONCLUSIONS
Critically ill COVID-19 patients in Singapore have lower venous thromboembolism but higher arterial thrombosis rates and bleeding manifestations than other reported cohorts.
摘要
背景
据报道，动脉和静脉血栓形成在危重症COVID-19患者中很常见。
方法与结果
这是一项全国性多中心回顾性观察研究，纳入了2020年1月23日至2020年4月30日期间在新加坡所有因需要入住重症监护病房（ICU）而连续收治的成年COVID-19患者。共纳入111例患者，ICU中的静脉和动脉血栓形成率分别为1.8%（n = 2）和9.9%（n = 11）。大出血率为14.8%（n = 16）。
结论
与其他报道的队列相比，新加坡的危重症COVID-19患者静脉血栓栓塞发生率较低，但动脉血栓形成率和出血表现较高。
相似文献
1
Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore.新加坡危重症新冠病毒肺炎患者静脉血栓形成发生率低，但动脉血栓形成并发症发生率高。
Thromb J. 2021 Mar 8;19(1):14. doi: 10.1186/s12959-021-00268-9.
2
Incidence of Thrombotic Events and Outcomes in COVID-19 Patients Admitted to Intensive Care Units.入住重症监护病房的新冠患者血栓形成事件及转归的发生率
Cureus. 2020 Oct 21;12(10):e11079. doi: 10.7759/cureus.11079.
3
High rate of bleeding and arterial thrombosis in COVID-19: Saudi multicenter study.新冠病毒肺炎患者中出血和动脉血栓形成的高发生率：沙特多中心研究
Thromb J. 2021 Mar 3;19(1):13. doi: 10.1186/s12959-021-00265-y.
4
Venous thromboembolism and bleeding in critically ill COVID-19 patients treated with higher than standard low molecular weight heparin doses and aspirin: A call to action.危重症 COVID-19 患者接受高于标准低分子肝素剂量和阿司匹林治疗时的静脉血栓栓塞和出血：行动呼吁。
Thromb Res. 2020 Dec;196:313-317. doi: 10.1016/j.thromres.2020.09.013. Epub 2020 Sep 13.
5
Incidence of thrombotic complications in COVID-19 : On behalf of ICODE: The International COVID-19 Thrombosis Biomarkers Colloquium.COVID-19 相关血栓性并发症的发生率：代表 ICODE：国际 COVID-19 血栓生物标志物研讨会。
J Thromb Thrombolysis. 2021 Nov;52(4):999-1006. doi: 10.1007/s11239-021-02475-7. Epub 2021 May 28.
6
Hemorrhage and venous thromboembolism in critically ill patients with COVID-19.新型冠状病毒肺炎危重症患者的出血与静脉血栓栓塞
SAGE Open Med. 2021 May 31;9:20503121211020167. doi: 10.1177/20503121211020167. eCollection 2021.
7
Thrombosis and hemorrhage in the critically ill cirrhotic patients: five years retrospective prevalence study.重症肝硬化患者的血栓形成与出血：五年回顾性患病率研究
Ann Hepatol. 2015 Jan-Feb;14(1):93-8.
8
Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19.COVID-19 患者的动脉和静脉血栓栓塞并发症登记册。
J Am Coll Cardiol. 2020 Nov 3;76(18):2060-2072. doi: 10.1016/j.jacc.2020.08.070.
9
Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors.内科-外科重症患者的深静脉血栓形成：患病率、发病率及危险因素
Crit Care Med. 2005 Jul;33(7):1565-71. doi: 10.1097/01.ccm.0000171207.95319.b2.
10
The modified NUTRIC score can be used for nutritional risk assessment as well as prognosis prediction in critically ill COVID-19 patients.改良的 NUTRIC 评分可用于危重症 COVID-19 患者的营养风险评估和预后预测。
Clin Nutr. 2021 Feb;40(2):534-541. doi: 10.1016/j.clnu.2020.05.051. Epub 2020 Jun 5.
引用本文的文献
1
Prevalence of Thromboembolic Events, Including Venous Thromboembolism and Arterial Thrombosis, in Patients with COVID-19: A Systematic Review with Meta-Analysis.2019冠状病毒病患者血栓栓塞事件（包括静脉血栓栓塞和动脉血栓形成）的患病率：一项系统评价与荟萃分析
J Tehran Heart Cent. 2023 Jul;18(3):154-169. doi: 10.18502/jthc.v18i3.14110.
2
Venous thromboembolism in an Asian COVID-19 cohort across 3 infection waves-a retrospective observational study.一项针对亚洲新冠病毒疾病（COVID-19）队列在三个感染波次中的静脉血栓栓塞症的回顾性观察研究。
Res Pract Thromb Haemost. 2023 Oct 11;7(7):102218. doi: 10.1016/j.rpth.2023.102218. eCollection 2023 Oct.
3
Thromboembolic Presentations among Patients Hospitalized to the Intensive Care Unit for Coronavirus Disease 2019 (COVID-19) - A Northern Taiwan Single Center Experience.2019冠状病毒病（COVID-19）重症监护病房住院患者的血栓栓塞表现——台湾北部单中心经验
Acta Cardiol Sin. 2023 Sep;39(5):695-708. doi: 10.6515/ACS.202309_39(5).20230203A.
4
Exploring heterogeneity in reported venous thromboembolism risk in COVID-19 and comparison to other viral pneumonias: a systematic review and meta-regression.探索COVID-19报告的静脉血栓栓塞风险的异质性并与其他病毒性肺炎进行比较：一项系统综述和Meta回归分析
Res Pract Thromb Haemost. 2023 Jul 13;7(5):102146. doi: 10.1016/j.rpth.2023.102146. eCollection 2023 Jul.
5
Beneficial effect of polyphenols in COVID-19 and the ectopic F F -ATP synthase: Is there a link?多酚在 COVID-19 及异位 F F -ATP 合酶中的有益作用：二者之间存在关联吗？
J Cell Biochem. 2022 Aug;123(8):1281-1284. doi: 10.1002/jcb.30306. Epub 2022 Jul 15.
6
The Mysterious Risk of Arterial Thrombosis With COVID-19: A Case Series and Systematic Review of Acute Limb Ischaemia.新型冠状病毒肺炎相关动脉血栓形成的神秘风险：急性肢体缺血病例系列及系统评价
Cureus. 2022 May 17;14(5):e25080. doi: 10.7759/cureus.25080. eCollection 2022 May.
7
Hypercoagulability, endotheliopathy, and inflammation approximating 1 year after recovery: Assessing the long-term outcomes in COVID-19 patients.恢复期 1 年后的高凝状态、血管内皮功能障碍和炎症：评估 COVID-19 患者的长期结局。
Am J Hematol. 2022 Jul;97(7):915-923. doi: 10.1002/ajh.26575. Epub 2022 Apr 28.
8
Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan.新型冠状病毒肺炎合并动静脉血栓形成：日本一项单中心回顾性分析
Front Cardiovasc Med. 2021 Nov 19;8:767074. doi: 10.3389/fcvm.2021.767074. eCollection 2021.
9
Global haemostatic tests demonstrate the absence of parameters of hypercoagulability in non-hypoxic mild COVID-19 patients: a prospective matched study.全球止血检测表明非缺氧性轻症 COVID-19 患者不存在高凝状态参数：一项前瞻性匹配研究。
J Thromb Thrombolysis. 2022 Apr;53(3):646-662. doi: 10.1007/s11239-021-02575-4. Epub 2021 Sep 28.
本文引用的文献
1
Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study.COVID-19 重症患者的血栓和出血并发症：一项多中心观察研究。
Crit Care. 2020 Sep 18;24(1):561. doi: 10.1186/s13054-020-03260-3.
2
Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019: CHEST Guideline and Expert Panel Report.新型冠状病毒肺炎患者静脉血栓栓塞症的预防、诊断和治疗：CHEST 指南和专家报告。
Chest. 2020 Sep;158(3):1143-1163. doi: 10.1016/j.chest.2020.05.559. Epub 2020 Jun 2.
3
Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill.新冠肺炎危重症患者血栓弹力图结果与高凝综合征。
JAMA Netw Open. 2020 Jun 1;3(6):e2011192. doi: 10.1001/jamanetworkopen.2020.11192.
4
COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.COVID-19 和凝血：SARS-CoV-2 感染的出血和血栓形成表现。
Blood. 2020 Jul 23;136(4):489-500. doi: 10.1182/blood.2020006520.
5
Thrombosis risk associated with COVID-19 infection. A scoping review.与 COVID-19 感染相关的血栓形成风险。范围综述。
Thromb Res. 2020 Aug;192:152-160. doi: 10.1016/j.thromres.2020.05.039. Epub 2020 May 27.
6
Coagulopathy of Coronavirus Disease 2019.新型冠状病毒疾病的凝血功能障碍。
Crit Care Med. 2020 Sep;48(9):1358-1364. doi: 10.1097/CCM.0000000000004458.
7
Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19.科学与标准化委员会通讯：新型冠状病毒肺炎住院患者静脉血栓栓塞症诊断、预防及治疗的临床指南
J Thromb Haemost. 2020 Aug;18(8):1859-1865. doi: 10.1111/jth.14929.
8
Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China: Prevalence, Risk Factors, and Outcome.中国武汉 COVID-19 住院患者的深静脉血栓形成：患病率、危险因素和结局。
Circulation. 2020 Jul 14;142(2):114-128. doi: 10.1161/CIRCULATIONAHA.120.046702. Epub 2020 May 18.
9
Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia.危重症 COVID-19 肺炎患者旋转血栓弹性描记术评估凝血功能。
J Thromb Thrombolysis. 2020 Aug;50(2):281-286. doi: 10.1007/s11239-020-02130-7.
10
Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis.确认 COVID-19 重症 ICU 患者的血栓并发症累积发生率较高：更新分析。
Thromb Res. 2020 Jul;191:148-150. doi: 10.1016/j.thromres.2020.04.041. Epub 2020 Apr 30.
Zotero 插件